DiazaChrysenes (DC): Nitrogen-Containing π-Extended Molecules for Photocatalytic C–H Amination Wei Xu, Atsushi Iwai, Itsuki Nagasaka, Satsuki Watanabe, Ryosuke Tsutsumi, and Naoya Kumagai* Org. Lett. 2025, 27, 10937–10942.
Enlarged-TriQuinoline (Enl-TQ): Disparity in Chemical Behaviors by Geometric Scaling of the Trimeric Quinoline Ring System Mai Yamashita, Ryosuke Tsutsumi, Toi Kobayashi, and Naoya Kumagai* Chem. Asian J.2025, 20, e00429.
iso-TEtraQuinoline (i-TEQ): An Inherently Chiral N4 Macrocyclic Quinoline Tetramer Ryota Yagami, Wei Xu, Toi Kobayashi, Yuuya Nagata, and Naoya Kumagai* Chem. Sci.2025, 16, 10714–10721.
キノリンを構成単位とする大環状システムの創出と多彩な化学への展開 (Development of Unique Quinoline–Based Macrocyclic Systems and Strategic Applications in Versatile Chemistry) Toi Kobayashi, Wei Xu, and Naoya Kumagai* J. Synth. Org. Chem. Jpn.2025, 83, 386–394.
DiQuinoline-MonoQuinazoline: A Flat Proton Binder and Its Application as a Polyaromatic Hydrocarbon Scavenger and G4 Ligand Taiga Karimata, Wei Xu, and Naoya Kumagai* Chem. Eur. J.2025, 31, e202404335.
In2Q2: A New Entry of 16-Membered Tetraazamacrocycle Concatenating Indole and Quinoline Units Kazuki Kihara, Toi Kobayashi, Wei Xu, and Naoya Kumagai* Chem. Eur. J.2024, 30, e202304176.
Recent Advances in Quinoline-based Macrocycles: Synthesis, Properties, and Applications in Catalytic Reactions Wei Xu and Naoya Kumagai* Synthesis2024, 56, 1765–1774.
Chemoselective Catalytic Dehydrogenation of Benzylic Amines Driven by TEtraQuinoline/FeCl2 Complex Mizuki Nishiwaki, Wei Xu, and Naoya Kumagai* Asian J. Org. Chem.2023, e202300261.
A Brief Introduction of Highly Symmetrical N-Heteroarene-based Heterocycles Wei Xu and Naoya Kumagai* Tetrahedron2023, 141, 133512.
Expeditious Access to the B3NO2 Heterocycle Enabling Modular Derivatization Ryosuke Tsutsumi, Nobuaki Kashiwagi, and Naoya Kumagai* J. Org. Chem.2023, 88, 6247–6251.
Azo-Tagged C4N4 Fluorophores: Unusual Overcrowded Structures and Their Applications to Fluorescent Imaging Miki Kohei, Naoki Takizawa, Ryosuke Tsutsumi, Wei Xu, and Naoya Kumagai* Org. Biomol. Chem.2023, 21, 2889–2893.
Less Is More: N(BOH)2 Configuration Exhibits Higher Reactivity than the B3NO2 Heterocycle in Catalytic Dehydrative Amide Formation Christopher R. Opie, Hidetoshi Noda,* Masakatsu Shibasaki, and Naoya Kumagai* Org. Lett.2023, 25, 694–697.
TEtraQuinolines: A Missing Link in the Family of Porphyrinoid Macrocycles Wei Xu, Yuuya Nagata, and Naoya Kumagai* J. Am. Chem. Soc.2023, 145, 2609–2618.
Oxygen-Fueled Iterative Hydride Transfer Driven by a Rigid Planar Architecture Taiga Karimata, Shinya Adachi, Masakatsu Shibasaki, and Naoya Kumagai* Chem. Pharm. Bull. 2022, 70, 595–598.
Highly Enantio- and Diastereoselective Synthesis of 1,2,3-Trisubstituted Cyclopropanes from α,β-Unsaturated Amides and Stabilized Sulfur Ylides Catalyzed by a Chiral Copper(I) Complex Santosh K. Pagire, Naoya Kumagai,* and Masakatsu Shibasaki* ACS Catal. 2021, 11, 11597–11606.
Strategic Synthesis of Asymmetrically Substituted C4N4 Fluorophores Wei Xu, Miki Kohei, Masakatsu Shibasaki,* and Naoya Kumagai* Synthesis 2021, 53, 3355–3360.
Direct Catalytic Asymmetric Addition of Aklylnitriles to Aldehydes with Designed Ni-Carbene Complexes Akira Saito, Shinya Adachi, Naoya Kumagai,* and Masakatsu Shibasaki* Angew. Chem. Int. Ed.2021, 60, 8739–8743.
Direct Catalytic Asymmetric Addition of α‐Fluoronitriles to Aldehydes Pandur V. Balaji, Zhao Li, Akira Saito, Naoya Kumagai,* and Masakatsu Shibasaki* Chem. Eur. J. 2020, 26, 15524–15527.
Design, Synthesis, and Application of Multiboron Heterocycle to Direct Amidation Catalyst Hidetoshi Noda, Masakatsu Shibasaki,* and Naoya Kumagai* J. Synth. Org. Chem. Jpn.2020, 78, 971–978.
The Different Faces of [Ru(bpy)3Cl2] and fac[Ir(ppy)3] Photocatalysts: Redox Potential Controlled Synthesis of Sulfonylated Fluorenes and Pyrroloindoles from Unactivated Olefins and Sulfonyl Chlorides Santosh K. Pagire, Naoya Kumagai,* and Masakatsu Shibasaki* Org. Lett. 2020, 22, 7853–7858.
Direct Catalytic Asymmetric and anti-Selective Vinylogous Addition of Butenolides to Chromones Jin Cui, Naoya Kumagai, Takumi Watanabe,* and Masakatsu Shibasaki* Chem. Sci.2020, 11, 7170–7176.
Introduction of a 7-Aza-6-MeO-indoline Auxiliary in Lewis acid/Photoredox Cooperative Catalysis: Highly Enantioselective Aminomethylation of α,β-Unsaturated Amides Santosh K. Pagire, Naoya Kumagai,* and Masakatsu Shibasaki* Chem. Sci. 2020, 11, 5168–5174.
Catalytic Asymmetric 1,3-Dipolar Cycloaddition of α,β-Unsaturated Amide and Azomethine Imine Zhao Li, Naoya Kumagai,* and Masakatsu Shibasaki* Chem. Pharm. Bull. 2020, 68, 552–554.
(2R,3S)-3,4,4,4-Tetrafluorovaline: A Fluorinated Bioisostere of Isoleucine Lennart Brewitz, Hidetoshi Noda, Naoya Kumagai,* and Masakatsu Shibasaki* Eur. J.Org. Lett. 2020, 1745–1752.
Z-Enolate Geometry in Thioamide Aldol Reaction Illuminated by 7-Azaindoline Auxiliary Roman Pluta, Zhao Li, Naoya Kumagai,* and Masakatsu Shibasaki* Org. Lett. 2020, 22, 791–794.
A Thirst for Enantioselectivity in Catalytic Asymmetric Addition of Alkylnitriles Naoya Kumagai* and Masakatsu Shibasaki* Chem. Lett.2019, 48, 1322–1327.
All Non-Carbon B3NO2 Exotic Heterocycle: Synthesis, Dynamics, and Catalysis Christopher R. Opie, Hidetoshi Noda, Masakatsu Shibasaki,* and Naoya Kumagai* Chem. Eur. J.2019, 25, 4648–4653.
A C4N4 Diaminopyrimidine Fluorophore Hidetoshi Noda, Yasuko Asada, Tatsuro Maruyama, Naoki Takizawa, Nobuo N. Noda, Masakatsu Shibasaki,* and Naoya Kumagai* Chem. Eur. J.2019, 25, 4299–4304.
Direct Catalytic Asymmetric Aldol Reaction of α-Alkoxyamides to α-Fluorinated Ketones Roman Pluta, Naoya Kumagai,* and Masakatsu Shibasaki* Angew. Chem. Int. Ed.2019, 58, 2459–2463.
Neighboring Protonation Unveils Lewis Acidity in the B3NO2 Heterocycle Hidetoshi Noda, Yasuko Asada, Masakatsu Shibasaki,* and Naoya Kumagai* J. Am. Chem. Soc.2019, 141, 1546–1554.
A Fluorogenic C4N4 Probe for Azide-Based Labelling Hidetoshi Noda, Yasuko Asada, Masakatsu Shibasaki,* and Naoya Kumagai* Org. Biomol. Chem. 2019, 17, 1813–1816.
Catalytic Asymmetric Synthesis of syn-Aldols with Methyl Ketone Functionality and anti-Aldol with a Thioamide Group Yuya Ota, Zhao Li, Naoya Kumagai,* and Masakatsu Shibasaki* Synlett2019, 30, 620–624.
Achiral Trisubstituted Thioureas as Secondary Ligands to Cu(I) Catalysts: Direct Catalytic Asymmetric Addition of α-Fluoronitriles to Imines Pandur Venkatesan Balaji, Lennart Brewitz, Naoya Kumagai,* and Masakatsu Shibasaki* Angew. Chem. Int. Ed. 2019, 58, 2644–2648.
Direct Catalytic Asymmetric Mannich-Type Reaction of an α-Isatine Amide to Isatin Imines Jin-Sheng Yu, Hidetoshi Noda, Naoya Kumagai,* and Masakatsu Shibasaki* Synlett2019, 30, 488–492.
7-Azaindoline Auxiliary: A Versatile Attachment Facilitating Enantioselective C–C Bond-Forming Catalysis Naoya Kumagai* and Masakatsu Shibasaki* Synthesis2019, 51, 185–193.
anti-Selective Catalytic Asymmetric Nitroaldol Reaction of α-Keto Esters: Intriguing Solvent Effect, Flow Reaction, and Synthesis of Active Pharmaceutical Ingredients Tomoya Karasawa, Raphaël Oriez, Naoya Kumagai,* and Masakatsu Shibasaki* J. Am. Chem. Soc. 2018, 140, 12290–12295.
Direct Catalytic Asymmetric 1,6-Conjugate Addition of Amides to p-Quinone Methides Zhongdong Sun, Bo Sun, Naoya Kumagai,* and Masakatsu Shibasaki* Org. Lett. 2018, 20, 3070–3073.
Direct Catalytic Asymmetric Aldol Reaction of α-vinyl Acetamide Toshifumi Takeuchi, Naoya Kumagai,* and Masakatsu Shibasaki* J. Org. Chem.2018, 83, 5851–5858.
Direct Enolization Chemistry of 7-Azaindoline Amides: A Case Study of Bis(tetrahydrophosphole)-type Ligands Zhao Li, Hidetoshi Noda, Naoya Kumagai,* and Masakatsu Shibasaki* Tetrahedron2018, 74, 3301–3305.
Direct Catalytic Asymmetric Aldol Reaction of Thioamide with an α-Vinyl Appendage Jin Cui, Akimichi Ohtsuki, Takumi, Watanabe,* Naoya Kumagai,* and Masakatsu Shibasaki* Chem.Eur. J. 2018, 24, 2598–2601.
Direct Catalytic Asymmetric Mannich-type Reaction En Route to α-Hydroxy-β-Amino Acid Derivatives Bo Sun, Roman Pluta, Naoya Kumagai,* and Masakatsu Shibasaki* Org.Lett. 2018, 20, 526–529.
Structural and Computational Investigation of Intramolecular N−H Interactions in α- and β-Fluorinated 7-Azaindoline Amides Lennart Brewitz, Hidetoshi Noda, Naoya Kumagai,* and Masakatsu Shibasaki* Eur. J. Org. Chem.2018, 714–722.
Bis(2-pyridyl)amides as Readily Cleavable Amides Under Catalytic, Neutral, and Room-Temperature Conditions Shinya Adachi, Naoya Kumagai,* and Masakatsu Shibasaki* Synlett2018, 29, 301–305.
Catalytic Asymmetric Synthesis of α-Trifluoromethylated Carbinols: A Case Study of Tertiary Propargylic Alcohols Hidetoshi Noda, Naoya Kumagai,* and Masakatsu Shibasaki* Asian J. Org. Chem.2018, 7, 599–612.
Conquering Amide Planarity: Structural Distortion and Its Hidden Reactivity Shinya Adachi, Naoya Kumagai,* and Masakatsu Shibasaki* TetrahedronLett. 2018, 59, 1147–1158.
α,β-Unsaturated Amides as Dipolarophiles: Catalytic Asymmetric Exo-selective 1,3-Dipolar Cycloaddition with Nitrones Ming Zhang, Naoya Kumagai,*and Masakatsu Shibasaki* Chem. Eur. J. 2017, 23, 12450–12455.
Catalytic Enantioselective Addition of Diethyl Phosphite to N-Thiophosphinoyl Ketimines: Preparation of (R)-Diethyl(1-amino-1-phenylethyl)phosphonate Shaoquan Lin, Yasunari Otsuka, Liang Yin, Naoya Kumagai,* and Masakatsu Shibasaki* Org. Synth.2017, 94, 313–331.
Direct Catalytic Asymmetric Aldol Addition of an α-CF3 Amide to Arylglyoxal Hydrates Akinobu Matsuzawa, Hidetoshi Noda, Naoya Kumagai,* Masakatsu Shibasaki* J. Org. Chem. 2017, 82, 8304–8308.
Photocatalytic α-Acylation of Ethers Zhongdong Sun, Naoya Kumagai,* Masakatsu Shibasaki* Org. Lett. 2017, 19, 3727–3730.
Direct N-Acylation of Sulfoximines with Carboxylic Acids Catalyzed by the B3NO2 Heterocycle Hidetoshi Noda, Yasuko Asada, Masakatsu Shibasaki,* and Naoya Kumagai* Chem. Commun.2017, 53, 7447–7450.
α-Halo Amides as Competent Latent Enolates: Direct Catalytic Asymmetric Mannich-type Reaction Bo Sun, Pandur Venkatesan Balaji, Naoya Kumagai,* and Masakatsu Shibasaki* J. Am. Chem. Soc. 2017, 139, 8295–8301.
Catalytic Asymmetric Synthesis of CF3-Substituted Tertiary Propargylic Alcohols via Direct Aldol Reaction of α-N3 Amide Hidetoshi Noda, Fuyuki Amemiya, Karin Weidner, Naoya Kumagai,* and Masakatsu Shibasaki* Chem. Sci.2017, 8(4), 3260–3269.
Reversible Stereoselective Folding/Unfolding Fueled by the Interplay of Photoisomerism and Hydrogen Bonding Christopher R. Opie, Naoya Kumagai,* and Masakatsu Shibasaki* Angew. Chem., Int. Ed.2017, 56, 3349–3353.
Unique Physicochemical and Catalytic Properties Dictated by the B3NO2 Ring System Hidetoshi Noda, Makoto Furutachi, Yasuko Asada, Masakatsu Shibasaki,* and Naoya Kumagai* Nature Chem.2017, 9, 571–577.
Asymmetric Flow Catalysis: Mix-and-Go Solid-Phase Nd/Na Catalyst for Expeditious Enantioselective Access to a Key Intermediate of AZD7594 Akihito Nonoyama, Naoya Kumagai,* and Masakatsu Shibasaki* Tetrahedron2017, 73, 1517–1521.
Direct Catalytic Asymmetric Aldol Reaction of α-Alkylamides Zijian Liu, Toshifumi Takeuchi, Roman Pluta, Fernando Arteaga Arteaga, Naoya Kumagai,* and Masakatsu Shibasaki* Org. Lett.2017, 19, 710–713.
Catalytic Asymmetric Synthesis of 2,3,3,3-Tetrafluoro-2-Methyl-1-Arylpropan-1-Amines as Useful Building Blocks for SAR-Studies Lennart Brewitz, Naoya Kumagai,* and Masakatsu Shibasaki* J. Fluor. Chem. 2017, 194, 1–7.
Pyramidalization/Twisting of the Amide Functional Group via Remote Steric Congestion Triggered by Metal Coordination Shinya Adachi, Naoya Kumagai,* and Masakatsu Shibasaki* Chem. Sci.2017, 8, 85–90.
Strategic Immobilization of Molecular Catalysts onto Carbon Nanotubes via Noncovalent Interaction for Catalytic Organic Transformation Naoya Kumagai* and Masakatsu Shibasaki* Isr, J. Chem.2017, 57, 270–280.
Enantioselective Synthesis of α,α-Disubstituted α-Amino Acids via Direct Catalytic Asymmetric Addition of Acetonitrile to α-Iminoester Shaoquan Lin, Naoya Kumagai,* and Masakatsu Shibasaki* Org. Biomol. Chem.2016, 14, 9725–9730.
Direct Catalytic Asymmetric Mannich-type Reaction of Alkylamides Fernando Arteaga Arteaga, Zijian Liu, Lennart Brewitz, Jianyang Chen, Bo Sun, Naoya Kumagai,* and Masakatsu Shibasaki* Org. Lett.2016, 18, 2391–2394.
Preparation of Nd/Na Heterogeneous Catalyst from Bench-Stable and Inexpensive Nd Salt for an anti-Selective Catalytic Asymmetric Nitroaldol Reaction Akihito Nonoyama, Kazuki Hashimoto, Akira Saito, Naoya Kumagai,* and Masakatsu Shibasaki* Tetrahedron Lett.2016, 57, 1815–1819.
Electrophilic Activation of α,β-Unsaturated Amides; Catalytic Asymmetric Vinylogous Conjugate Addition of Unsaturated γ-Butyrolactones Ming Zhang, Naoya Kumagai,* and Masakatsu Shibasaki* Chem. Eur. J.2016, 22, 5525–5529.
Direct Catalytic Asymmetric Mannich-type Reaction of α,β-Unsaturated γ-Butyrolactam to Ketimines Shaoquan Lin, Naoya Kumagai,* and Masakatsu Shibasaki* Chem. Eur. J.2016, 22, 3296–3299.
Nucleophilic and Electrophilic Activation of Non-Heteroaromatic Amides in Atom Economical Asymmetric Catalysis Naoya Kumagai* and Masakatsu Shibasaki* Chem. Eur. J.2016, 22, 15192–15200.
Career in Catalysis: Masakatsu Shibasaki Naoya Kumagai,* Motomu Kanai,* and Hiroaki Sasai* ACS Catal.2016, 6, 4699–4709.
Direct Catalytic Asymmetric Mannich-type Reaction of α- and β-Fluorinated Amides Lennart Brewitz, Fernando Arteaga Arteaga, Liang Yin, Kaliyamoorthy Alagiri, Naoya Kumagai,* and Masakatsu Shibasaki* J. Am. Chem. Soc. 2015, 137, 15929–15939.
Direct Catalytic Asymmetric Mannich-type Reaction of α-N3 Amide Zhongdong Sun, Karin Weidner, Naoya Kumagai,* and Masakatsu Shibasaki* Chem. Eur. J.2015, 21, 17574–17577.
Stereoselective Total Synthesis of KAE609 via Direct Catalytic Asymmetric Alkynylation to Ketimine Hisashi Takada, Naoya Kumagai,* and Masakatsu Shibasaki* Org. Lett. 2015, 17, 4762–4765.
Managing the Retro-Pathway in Direct Catalytic Asymmetric Aldol Reactions of Thioamides Youmei Bao, Naoya Kumagai,* and Masakatsu Shibasaki* Chem. Sci.2015, 6, 6124–6132.
Direct Catalytic Asymmetric Conjugate Addition of Saturated and Unsaturated Thioamides Nilanjana Majumdar, Akira Saito, Liang Yin, Naoya Kumagai,* and Masakatsu Shibasaki* Org. Lett. 2015, 17, 3362–3365.
Direct Catalytic Asymmetric Mannich-type Reaction of Benzyl Isocyanide: Stereoselective Synthesis of 1,2-Diarylethylenediamines Keiji Tamura, Naoya Kumagai,* and Masakatsu Shibasaki* Eur. J. Org. Chem. 2015, 3026–3031.
Direct Catalytic Asymmetric Aldol Reaction of α-N3 Amide Karin Weidner, Zhongdong Sun, Naoya Kumagai,* and Masakatsu Shibasaki* Angew. Chem., Int. Ed.2015, 54, 6236–6240.
Catalytic Asymmetric Mannich-type Reaction of N-Alkylidene α-Aminoacetonitrile to Ketimines Shaoquan Lin, Yuji Kawato, Naoya Kumagai,* and Masakatsu Shibasaki* Angew. Chem., Int. Ed.2015, 54, 5183–5186.
A Carbon Nanotube Confinement Strategy to Implement Homogeneous Asymmetric Catalysis in the Solid Phase Kazuki Hashimoto, Naoya Kumagai,* and Masakatsu Shibasaki* Chem. Eur. J.2015, 21, 4262–4266.
Recent Advances in Catalytic Asymmetric C–C Bond-Forming Reactions to Ketimines Promoted by Metal-Based Catalysts Naoya Kumagai* and Masakatsu Shibasaki* Bull. Chem. Soc. Jpn.2015, 88, 503–517.
Catalytic Generation of α-CF3 Enolate: Direct Catalytic Asymmetric Mannich-type Reaction of α-CF3 Amide Liang Yin, Lennart Brewitz, Naoya Kumagai,* and Masakatsu Shibasaki* J. Am. Chem. Soc. 2014, 136, 17958–17961.
Chromatography-Free Synthesis of Corey’s Intermediate for Tamiflu Makoto Furutachi, Naoya Kumagai, Takumi Watanabe,* and Masakatsu Shibasaki* Tetrahedron2014, 70, 9113–9117.
Iterative Direct Aldol Strategy for Polypropionates: Enantioselective Total Synthesis of (–)-Membrenone A and B Kaliyamoorthy Alagiri, Naoya Kumagai,* and Masakatsu Shibasaki* Org. Lett.2014, 16, 5301–5303.
Design and Synthesis of a Bis(hydroxyphenyl)diamide Bearing a Pendant Thiazolium Unit; Application to the Catalytic Asymmetric Intramolecular Stetter Reaction Youmei Bao, Naoya Kumagai,* and Masakatsu Shibasaki* Tetrahedron: Asymmetry2014, 25, 1401–1408.
Direct Catalytic Addition of Alkylnitriles to Aldehydes by Transition Metal/NHC Complexes Devarajulu Sureshkumar, Venkataraman Ganesh, Naoya Kumagai,* and Masakatsu Shibasaki* Chem. Eur. J.2014, 20, 15723–15726.
Self-Assembled Asymmetric Catalyst Engaged in a Continuous-Flow Platform: An anti-Selective Catalytic Asymmetric Nitroaldol Reaction Kazuki Hashimoto, Naoya Kumagai,* Masakatsu Shibasaki* Org. Lett.2014, 16, 3496–3499.
A Designed Amide as an Aldol Donor in the Direct CatalyticAsymmetric Aldol Reaction Karin Weidner, Naoya Kumagai,* and Masakatsu Shibasaki* Angew. Chem., Int. Ed.2014, 53, 6150–6154.
Concise Enantioselective Synthesis of δ,δ-Disubstituted δ-Valerolactones Akira Saito, Naoya Kumagai,* and Masakatsu Shibasaki* Tetrahedron Lett. 2014, 55, 3167–3171.
An Enantioselective Synthesis of the Key Intermediate for Triazole Antifungal Agents; Application to the Catalytic Asymmetric Synthesis of Efinaconazole (Jublia®) Keiji Tamura, Naoya Kumagai,* and Masakatsu Shibasaki* J. Org. Chem. 2014, 79, 3272–3278.
Direct Catalytic Asymmetric Vinylogous Conjugate Addition of Unsaturated Butyrolactones to α,β-Unsaturated Thioamides Liang Yin, Hisashi Takada, Shaoquan Lin, Naoya Kumagai,* Masakatsu Shibasaki* Angew. Chem., Int. Ed.2014, 53, 5327–5331.
Direct Aldol Strategy in Enantioselective Total Synthesis of Thuggacin B Akinobu Matsuzawa, Christopher R. Opie, Naoya Kumagai,* Masakatsu Shibasaki* Chem. Eur. J.2014, 20, 68–71.
A Modified Preparation Procedure for Carbon Nanotube-Confined Nd/Na Heterobimetallic Catalyst for anti-Selective Catalytic Asymmetric Nitroaldol Reactions Devarajulu Sureshkumar, Kazuki Hashimoto, Naoya Kumagai,* and Masakatsu Shibasaki* J. Org. Chem. 2013, 78, 11494–11500.
Direct Catalytic Asymmetric Addition of Acetonitrile to N-Thiophosphinoylimines Yuji Kawato, Naoya Kumagai,* and Masakatsu Shibasaki* Chem. Commun.2013, 49, 11227–11229.
In situ Manipulation of Catalyst Performance via Photocontrolled Aggregation/Dissociation State of the Catalyst Akihiro Nojiri, Naoya Kumagai,* and Masakatsu Shibasaki* Chem. Commun.2013, 49, 4628–4630.
Two Approaches toward the Formal Total Synthesis of Oseltamivir Phosphate (Tamiflu®): Catalytic Enantioselective Three-Component Reaction Strategy and L-Glutamic Acid Strategy Kaliyamoorthy Alagiri, Makoto Furutachi, Kenzo Yamatsugu, Naoya Kumagai, Takumi Watanabe,* and Masakatsu Shibasaki* J. Org. Chem. 2013, 78, 4019–4026.
Streamlined Catalytic Asymmetric Synthesis of Atorvastatin Yuji Kawato, Sandeep Chaudhary, Naoya Kumagai,* and Masakatsu Shibasaki* Chem. Eur. J.2013, 19, 3802–3806.
Direct Catalytic Asymmetric Alkynylation of Ketoimines Liang Yin, Yasunari Otsuka, Hisashi Takada, Shinsuke Mouri, Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki* Org. Lett 2013, 15, 698–701.
Direct Catalytic Asymmetric Addition of Allylic Cyanides to Aldehydes for Expeditious Access to Enantioenriched Unsaturated δ-Valerolactones Yasunari Otsuka, Hisashi Takada, Shigeo Yasuda, Naoya Kumagai,* and Masakatsu Shibasaki* Chem. Asian J. 2013, 8, 354–358.
Asymmetric Catalysis with Bis(hydroxyphenyl)diamides/Rare Earth Metal Complexes Naoya Kumagai* and Masakatsu Shibasaki* Angew. Chem., Int. Ed. 2013, 52, 223–234.
Catalytic Chemical Transformations with Conformationally Dynamic Catalytic Systems Naoya Kumagai* and Masakatsu Shibasaki* Catal. Sci. Technol. 2013, 3, 41–57.
Direct Asymmetric α-Allylation of Ketones with Allylic Alcohols via Pd/Enamine Cooperative Function Shigeo Yasuda, Naoya Kumagai,* and Masakatsu Shibasaki* Heterocycles2012, 86, 745–757.
Catalytic Asymmetric Conjugate Addition of Thiols to α,β-Unsaturated Thioamides: Expeditious Access to Enantioenriched 1,5-Benzothiazepines Takanori Ogawa, Naoya Kumagai,* and Masakatsu Shibasaki* Angew. Chem., Int. Ed. 2012, 51, 8551–8554.
anti-Selective Direct Catalytic Asymmetric Aldol Reaction of Thiolactams Devarajulu Sureshkumar, Yuji Kawato, Mitsutaka Iwata, Naoya Kumagai,* and Masakatsu Shibasaki* Org. Lett. 2012, 14, 3108–3111.
Concise Enantioselective Synthesis of Duloxetine via Direct Catalytic Asymmetric Aldol Reaction of Thioamide Yuta Suzuki, Mitsutaka Iwata, Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki* J. Org. Chem.2012, 77, 4496–4500.
A Direct Catalytic Asymmetric Aldol Reaction of α-Sulfanyl Lactones: Efficient Synthesis of SPT Inhibitors Sho Takechi, Shigeo Yasuda, Naoya Kumagai,* and Masakatsu Shibasaki* Angew. Chem., Int. Ed. 2012, 51, 4218-4222.
Reversible Heterochiral Aggregation/Dissociation of Bis(2-hydroxyphenyl)diamides Driven by UV/Vis Irradiation Akihiro Nojiri, Naoya Kumagai,* and Masakatsu Shibasaki* Angew. Chem., Int. Ed. 2012, 51, 2137–2141.
Catalytic Asymmetric anti-Selective Nitroaldol Reaction En Route to Zanamivir Tatsuya Nitabaru, Naoya Kumagai,* and Masakatsu Shibasaki* Angew. Chem., Int. Ed. 2012, 51, 1644–1647.
Intermediate as Catalyst; Catalytic Asymmetric Conjugate Addition of Nitroalkanes to α,β-Unsaturated Thioamides Takanori Ogawa, Shinsuke Mouri, Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki* Org. Lett.2012, 14, 110–113.
Cooperative Catalysis Using Thioamides Toward Truly Practical Organic Synthesis Naoya Kumagai* and Masakatsu Shibasaki* Isr. J. Chem. 2012, 52, 604–612.
Direct Catalytic Asymmetric Intramolecular Conjugate Addition of Thioamide to α,β-Unsaturated Esters Yuta Suzuki, Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki* Chem.Eur. J. 2011, 17, 11998–12001.
Asymmetric Synthesis of Isothiazoles Through Cu Catalysis: Direct Catalytic Asymmetric Conjugate Addition of Allyl Cyanide to α,β-Unsaturated Thioamides Yuka Yanagida, Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki* Angew. Chem., Int. Ed. 2011, 50, 7910–7914.
A Simplified Catalytic System for Direct Catalytic Asymmetric Aldol Reaction of Thioamides; Application to an Enantioselective Synthesis of Atorvastatin Yuji Kawato, Mitsutaka Iwata, Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki* Tetrahedron 2011, 67, 6539–6546.
Direct Catalytic Enantio- and Diastereoselective Aldol Reaction of Thioamides Mitsutaka Iwata, Ryo Yazaki, I-Hon Chen, Devarajulu Sureshkumar, Naoya Kumagai,* and Masakatsu Shibasaki* J. Am. Chem. Soc. 2011, 133, 5554–5560.
Cooperative Activation of Alkyne and Thioamide Functionalities; Direct Catalytic Asymmetric Conjugate Addition of Terminal Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki* Chem. Asian J. 2011, 6, 1778–1790.
Enantioselective Synthesis of a GPR40 Agonist AMG 837 via Catalytic Asymmetric Conjugate Addition of Terminal Alkyne to α,β-Unsaturated Thioamide Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki* Org. Lett. 2011, 13, 952–955.
Catalytic Asymmetric Hydroxylation of α-Alkoxycarbonyl Amides with a Pr(OiPr)3/Amide-Based Ligand Catalyst Sho Takechi, Naoya Kumagai,* and Masakatsu Shibasaki* Tetrahedron Lett. 2011, 52, 2140–2143.
Catalytic Asymmetric Amination of N-Nonsubstituted α-Alkoxycarbonyl Amides: Concise Enantioselective Synthesis of Mycestericin F and G Farouk Berhal, Sho Takechi, Naoya Kumagai,* and Masakatsu Shibasaki* Chem. Eur. J.2011, 17, 1915–1921.
Expanding Stereochemical and Skeletal Diversity Derived from Petasis Reactions Using 1,3-Dipolar Cycloadditions Giovanni Muncipinto, Taner Kaya, J. Anthony Wilson, Naoya Kumagai, Paul A. Clemons, and Stuart L. Schreiber* Org. Lett.2010, 12, 5230–5233.
Recent Advances in Direct Catalytic Asymmetric Transformations Under Proton-Transfer Conditions Naoya Kumagai* and Masakatsu Shibasaki* Angew. Chem., Int. Ed. 2011, 50, 4760–4772.
Development of Atom-Economical Catalytic Asymmetric Reactions Under Proton Transfer Conditions: Construction of Tetrasubstituted Stereogenic Centers and Their Application to Therapeutics Naoya Kumagai* Chem. Pharm. Bull.2011, 59, 1–22.
Direct Catalytic Asymmetric Conjugate Addition of Terminal Alkynes to α,β-Unsaturated Thioamides Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki* J. Am. Chem. Soc.2010, 132, 10275–10277.
Direct Catalytic Asymmetric Aldol Reaction of Thioamides: A Concise Asymmetric Synthesis of (R)-Fluoxetine Mitsutaka Iwata, Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki* Tetrahedron: Asymmetry2010, 21, 1688–1694.
Solvent-Dependent Self-Discrimination of Bis(2-hydroxyphenyl)diamides Akinobu Matsuzawa, Akihiro Nojiri, Naoya Kumagai,* and Masakatsu Shibasaki* Chem. Eur. J.2010, 16, 5036–5042.
Direct Catalytic Asymmetric Addition of Allyl Cyanide to Ketones via Soft Lewis Acid/Hard Brønsted Base/Hard Lewis Base Catalysis Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki* J. Am. Chem. Soc.2010, 132, 5522–5531.
Catalytic Asymmetric Conjugate Addition of α-Cyanoketones For the Construction of a Quaternary Stereogenic Center Yuji Kawato, Noriko Takahashi, Naoya Kumagai,* and Masakatsu Shibasaki* Org. Lett. 2010, 12, 1484–1487.
Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst Tatsuya Nitabaru, Naoya Kumagai,* and Masakatsu Shibasaki* Molecules2010, 15, 1280–1290.
Direct Catalytic Asymmetric Aldol Reactions of Thioamides: Toward a Stereocontrolled Synthesis of 1,3-Polyols Iwata, Ryo Yazaki, Yuta Suzuki, Naoya Kumagai,* and Masakatsu Shibasaki* J. Am. Chem. Soc. 2009, 131, 18244–18245.
Managing Highly Coordinative Substrates in Asymmetric Catalysis: a Catalytic Asymmetric Amination with a Lanthanum-based Ternary Catalyst Tomoyuki Mashiko, Naoya Kumagai,* and Masakatsu Shibasaki* J. Am. Chem. Soc.2009, 131, 14990–14999.
anti-Selective Catalytic Asymmetric Nitroaldol Reaction via a Heterobimetallic Heterogeneous Catalyst Tatsuya Nitabaru, Akihiro Nojiri, Makoto Kobayashi, Naoya Kumagai,* and Masakatsu Shibasaki* J. Am. Chem. Soc.2009, 131, 13860–13869.
Direct Catalytic Asymmetric Mannich-type Reaction of Thioamides Yuta Suzuki, Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki* Angew. Chem., Int. Ed. 2009, 48, 5026–5029.
Linking Structural Dynamics and Functional Diversity in Asymmetric Catalysis Akihiro Nojiri, Naoya Kumagai,* and Masakatsu Shibasaki* J. Am. Chem. Soc. 2009, 131, 3779–3784.
Direct Catalytic Asymmetric Addition of Allyl Cyanide to Ketones Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki* J. Am. Chem. Soc. 2009, 131, 3195–3197.
Recent Progress in Asymmetric Bifunctional Catalysis Using Multimetallic Systems Masakatsu Shibasaki,* Motomu Kanai, Shigeki Matsunaga, and Naoya Kumagai Acc. Chem. Res.2009, 42, 1117–1127.
Direct Catalytic Asymmetric Addition of Allylic Cyanides to Ketoimines Ryo Yazaki, Tatsuya Nitabaru, Naoya Kumagai,* and Masakatsu Shibasaki* J. Am. Chem. Soc. 2008, 130, 14477–14479.
An Improved Lanthanum Catalyst System for Asymmetric Amination; Toward a Practical Asymmetric Synthesis of AS-3201 (Ranirestat) Tomoyuki Mashiko, Naoya Kumagai,* and Masakatsu Shibasaki* Org. Lett. 2008, 10, 2725–2728.
Asymmetric Catalysis via Dynamic Substrate/Ligand/Rare Earth Metal Conglomerate Akihiro Nojiri, Naoya Kumagai,* and Masakatsu Shibasaki* J. Am. Chem. Soc.2008, 130, 5630–5631.
A Catalytic Asymmetric anti-Selective Nitroaldol Reaction with a Neodymium-Sodium Heterobimetallic Complex Tatsuya Nitabaru, Naoya Kumagai,* and Masakatsu Shibasaki* Tetrahedron Lett.2008, 49, 272–276.
En Route to an Efficient Catalytic Asymmetric Synthesis of AS-3201 Tomoyuki Mashiko, Keiichi Hara, Daisuke Tanaka, Yuji Fujiwara, Naoya Kumagai,* and Masakatsu Shibasaki* J. Am. Chem. Soc.2007, 129, 11342–11343.
Catalytic Nucleophilic Activation of Acetonitrile via a Cooperative Catalysis of Cationic Ru Complex, DBU, and NaPF6 Naoya Kumagai,* Shigeki Matsunaga, and Masakatsu Shibasaki* Tetrahedron 2007, 63, 8598–8608.
Short Synthesis of Skeletally and Stereochemically Diverse Small Molecules by Coupling Petasis Condensation Reactions to Cyclization Reactions Naoya Kumagai,Giovanni Muncipinto, and Stuart L. Schreiber* Angew. Chem., Int. Ed. 2006, 45, 3635–3638.
Catalytic Chemoselective Addition of Acetonitrile to Enolizable Aldehydes with Cationic Ru Complex/DBU Combination Naoya Kumagai, Shigeki Matsunaga, and Masakatsu Shibasaki* Chem. Commun.2005, 3600–3602.
Non-C2-symmetric, Chirally Economical, and Readily Tunable Linked-BINOLs: Design and Application in Direct Asymmetric Mannich-type Reaction Takamasa Yoshida, Hiroyuki Morimoto, Naoya Kumagai, Shigeki Matsunaga, and Masakatsu Shibasaki* Angew. Chem. Int. Ed.2005, 44, 3470–3474.
An Efficient Synthesis of Bicyclic Amidines by Intramolecular Cyclization Naoya Kumagai, Shigeki Matsunaga, and Masakatsu Shibasaki* Angew. Chem., Int. Ed. 2004, 43, 478–482
Direct catalytic Asymmetric Mannich-type Reaction of Hydroxyketone Using a Et2Zn/linked-BINOL Complex: Synthesis of Either anti-α or syn-β-Amino Alcohols Shigeki Matsunaga, Takamasa Yoshida, Hiroyuki Morimoto, Naoya Kumagai, and Masakatsu Shibasaki* J. Am. Chem. Soc.2004, 126, 8277–8785.
Cooperative Catalysis of a Cationic Ruthenium Complex, Amine Base, and Na Salt: Catalytic Activation of Acetonitrile as Nucleophile Naoya Kumagai, Shigeki Matsunaga, and Masakatsu Shibasaki* J. Am. Chem. Soc.2004, 126, 13632–13633.
Direct Catalytic Aldol-Type Reactions Using RCH2CN Yutaka Suto, Naoya Kumagai, Shigeki Matsunaga, Motomu Kanai, and Maskatsu Shibasaki* Org. Lett.2003, 5, 3147–3150.
anti-Selective Direct Catalytic Asymmetric Mannich-type Reaction of Hydroxyketone Providing β-Amino Alcohols Shigeki Matsunaga, Naoya Kumagai, Shinji Harada, and Masakatsu Shibasaki* J. Am. Chem. Soc. 2003, 125, 4712–4713.
Direct Catalytic Asymmetric Michael Reaction of Hydroxyketones: Asymmetric Zn Catalysis with a Et2Zn/Linked-BINOL Complex Shinji Harada, Naoya Kumagai, Tomofumi Kinoshita, Shigeki Matsunaga, and Masakatsu Shibasaki* J. Am. Chem. Soc. 2003, 125, 2582–2590.
Direct Catalytic Asymmetric Aldol Reaction of Hydroxyketones: Asymmetric Zn Catalysis with a Et2Zn/Linked-BINOL Complex Naoya Kumagai, Shigeki Matsunaga, Tomofumi Kinoshita, Shinji Harada, Shigemitsu Okada, Shigeru Sakamoto, Kentaro Yamaguchi, and Masakatsu Shibasaki* J. Am. Chem. Soc. 2003, 125, 2169–2178.
Enantioselective 1,4-Addition of Unmodified Ketone Catalyzed by a Bimetallic Zn-Zn-linked-BINOL Complex Naoya Kumagai, Shigeki Matsunaga and Masakatsu Shibasaki* Org. Lett. 2001, 3, 4251–4254.
Direct Catalytic Enantio- and Diastereoselective Aldol Reaction Using a Zn-Zn-Linked-BINOL Complex: A Practical Synthesis of syn-1,2-Diols Naoya Kumagai, Shigeki Matsunaga, Naoki Yoshikawa, Takashi Ohshima, and Masakatsu Shibasaki* Org. Lett. 2001, 3, 1539–1542.
Direct Catalytic Asymmetric Aldol Reaction: Synthesis of Either syn– or anti-α,β-Dihydroxyketones Naoki Yoshikawa, Naoya Kumagai, Shigeki Matsunaga, Guido Moll, Takashi Ohshima, Takeyuki Shzuki, and Masakatsu Shibasaki* J. Am. Chem. Soc. 2001, 123, 2466–2467.
An Efficient Method for the Synthesis of Versatile Intermediate Leading to 13-Deoxy- and 9,13-Dideoxyphorbors Akihiro Sekine, Naoya Kumagai, Koichiro Uotsu, Takashi Ohshima, and Masakatsu Shibasaki* Tetrahedron Lett. 2000, 41, 509–513.
