ALL

PUBLICATIONS

  • DiQuinoline-MonoQuinazoline: A Flat Proton Binder and Its Application as a Polyaromatic Hydrocarbon Scavenger and G4 Ligand
    Taiga Karimata, Wei Xu, and Naoya Kumagai*
    Chem. Eur. J. in press.
  • In2Q2: A New Entry of 16-Membered Tetraazamacrocycle Concatenating Indole and Quinoline Units
    Kazuki Kihara, Toi Kobayashi, Wei Xu, and Naoya Kumagai*
    Chem. Eur. J. 2024, 30, e202304176.
  • Recent Advances in Quinoline-based Macrocycles: Synthesis, Properties, and Applications in Catalytic Reactions
    Wei Xu and Naoya Kumagai*
    Synthesis 2024, 56, 1765–1774.
  • Peripheral Modification of Tripodal Aza-Oxa-Crown oxa-TriQuinoline
    Toi Kobayashi, Takuya Sakurai, and Naoya Kumagai*
    Bull. Chem. Soc. Jpn. 2023, 96, 1139–1143.
  • Oxa-TriQuinoline: A New Entry to Aza-Oxa-Crown Architectures
    Toi Kobayashi and Naoya Kumagai*
    Angew. Chem. Int. Ed., 2023, 62, e202307896.
  • Chemoselective Catalytic Dehydrogenation of Benzylic Amines Driven by TEtraQuinoline/FeCl2 Complex
    Mizuki Nishiwaki, Wei Xu, and Naoya Kumagai*
    Asian J. Org. Chem., 2023, e202300261.
  • A Brief Introduction of Highly Symmetrical N-Heteroarene-based Heterocycles
    Wei Xu and Naoya Kumagai*
    Tetrahedron, 2023, 141, 133512.
  • Expeditious Access to the B3NO2 Heterocycle Enabling Modular Derivatization
    Ryosuke Tsutsumi, Nobuaki Kashiwagi, and Naoya Kumagai*
    J. Org. Chem. 2023, 88, 6247–6251.
  • Azo-Tagged C4N4 Fluorophores: Unusual Overcrowded Structures and Their Applications to Fluorescent Imaging
    Miki Kohei, Naoki Takizawa, Ryosuke Tsutsumi, Wei Xu, and Naoya Kumagai*
    Org. Biomol. Chem. 2023, 21, 2889–2893.
  • Less Is More: N(BOH)2 Configuration Exhibits Higher Reactivity than the B3NO2 Heterocycle in Catalytic Dehydrative Amide Formation
    Christopher R. Opie, Hidetoshi Noda,* Masakatsu Shibasaki, and Naoya Kumagai*
    Org. Lett. 2023, 25, 694–697.
  • TEtraQuinolines: A Missing Link in the Family of Porphyrinoid Macrocycles
    Wei Xu, Yuuya Nagata, and Naoya Kumagai*
    J. Am. Chem. Soc. 2023, 145, 2609–2618.
  • Oxygen-Fueled Iterative Hydride Transfer Driven by a Rigid Planar Architecture
    Taiga Karimata, Shinya Adachi, Masakatsu Shibasaki, and Naoya Kumagai*
    Chem. Pharm. Bull. 2022, 70, 595–598.
  • Highly Enantio- and Diastereoselective Synthesis of 1,2,3-Trisubstituted Cyclopropanes from α,β-Unsaturated Amides and Stabilized Sulfur Ylides Catalyzed by a Chiral Copper(I) Complex
    Santosh K. Pagire, Naoya Kumagai,* and Masakatsu Shibasaki*
    ACS Catal. 2021, 11, 11597–11606.
  • Strategic Synthesis of Asymmetrically Substituted C4N4 Fluorophores
    Wei Xu, Miki Kohei, Masakatsu Shibasaki,* and Naoya Kumagai*
    Synthesis 2021, 53, 3355–3360.
  • Direct Catalytic Asymmetric Addition of Aklylnitriles to Aldehydes with Designed Ni-Carbene Complexes
    Akira Saito, Shinya Adachi, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem. Int. Ed. 2021, 60, 8739–8743.
  • Direct Catalytic Asymmetric Addition of α‐Fluoronitriles to Aldehydes
    Pandur V. Balaji, Zhao Li, Akira Saito, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Eur. J. 2020, 26, 15524–15527.
  • Design, Synthesis, and Application of Multiboron Heterocycle to Direct Amidation Catalyst
    Hidetoshi Noda, Masakatsu Shibasaki,* and Naoya Kumagai*
    J. Synth. Org. Chem. Jpn. 2020, 78, 971–978.
  • The Different Faces of [Ru(bpy)3Cl2] and fac[Ir(ppy)3] Photocatalysts: Redox Potential Controlled Synthesis of Sulfonylated Fluorenes and Pyrroloindoles from Unactivated Olefins and Sulfonyl Chlorides
    Santosh K. Pagire, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2020, 22, 7853–7858.
  • Direct Catalytic Asymmetric and anti-Selective Vinylogous Addition of Butenolides to Chromones
    Jin Cui, Naoya Kumagai, Takumi Watanabe,* and Masakatsu Shibasaki*
    Chem. Sci. 2020, 11, 7170–7176.
  • Introduction of a 7-Aza-6-MeO-indoline Auxiliary in Lewis acid/Photoredox Cooperative Catalysis: Highly Enantioselective Aminomethylation of α,β-Unsaturated Amides
    Santosh K. Pagire, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Sci. 2020, 11, 5168–5174.
  • Catalytic Asymmetric 1,3-Dipolar Cycloaddition of α,β-Unsaturated Amide and Azomethine Imine
    Zhao Li, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Pharm. Bull. 2020, 68, 552–554.
  • (2R,3S)-3,4,4,4-Tetrafluorovaline: A Fluorinated Bioisostere of Isoleucine
    Lennart Brewitz, Hidetoshi Noda, Naoya Kumagai,* and Masakatsu Shibasaki*
    Eur. J. Org. Lett. 2020, 1745–1752.
  • Z-Enolate Geometry in Thioamide Aldol Reaction Illuminated by 7-Azaindoline Auxiliary
    Roman Pluta, Zhao Li, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2020, 22, 791–794.
  • TriQuinoline
    Shinya Adachi, Masakatsu Shibasaki, and Naoya Kumagai*
    Nature Commun. 2019, 10, 3820.
  • Direct Catalytic Asymmetric Addition of Acetonitrile to Aldimines
    Akira Saito, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2019, 21, 8187–8190.
  • Solvent-Dependent Enantio-divergence in anti-Selective Catalytic Asymmetric Nitroaldol Reactions
    Tomoya Karasawa, Akira Saito, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2019, 21, 3581–3583.
  • A Thirst for Enantioselectivity in Catalytic Asymmetric Addition of Alkylnitriles
    Naoya Kumagai* and Masakatsu Shibasaki*
    Chem. Lett. 2019, 48, 1322–1327.
  • All Non-Carbon B3NO2 Exotic Heterocycle: Synthesis, Dynamics, and Catalysis
    Christopher R. Opie, Hidetoshi Noda, Masakatsu Shibasaki,* and Naoya Kumagai*
    Chem. Eur. J. 2019, 25, 4648–4653.
  • A C4N4 Diaminopyrimidine Fluorophore
    Hidetoshi Noda, Yasuko Asada, Tatsuro Maruyama, Naoki Takizawa, Nobuo N. Noda, Masakatsu Shibasaki,* and Naoya Kumagai*
    Chem. Eur. J. 2019, 25, 4299–4304.
  • Direct Catalytic Asymmetric Aldol Reaction of α-Alkoxyamides to α-Fluorinated Ketones
    Roman Pluta, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem. Int. Ed. 2019, 58, 2459–2463.
  • Neighboring Protonation Unveils Lewis Acidity in the B3NO2 Heterocycle
    Hidetoshi Noda, Yasuko Asada, Masakatsu Shibasaki,* and Naoya Kumagai*
    J. Am. Chem. Soc. 2019, 141, 1546–1554.
  • A Fluorogenic C4N4 Probe for Azide-Based Labelling
    Hidetoshi Noda, Yasuko Asada, Masakatsu Shibasaki,* and Naoya Kumagai*
    Org. Biomol. Chem. 2019, 17, 1813–1816.
  • Catalytic Asymmetric Synthesis of syn-Aldols with Methyl Ketone Functionality and anti-Aldol with a Thioamide Group
    Yuya Ota, Zhao Li, Naoya Kumagai,* and Masakatsu Shibasaki*
    Synlett 2019, 30, 620–624.
  • Achiral Trisubstituted Thioureas as Secondary Ligands to Cu(I) Catalysts: Direct Catalytic Asymmetric Addition of α-Fluoronitriles to Imines
    Pandur Venkatesan Balaji, Lennart Brewitz, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem. Int. Ed. 2019, 58, 2644–2648.
  • Direct Catalytic Asymmetric Mannich-Type Reaction of an α-Isatine Amide to Isatin Imines
    Jin-Sheng Yu, Hidetoshi Noda, Naoya Kumagai,* and Masakatsu Shibasaki*
    Synlett 2019, 30, 488–492.
  • 7-Azaindoline Auxiliary: A Versatile Attachment Facilitating Enantioselective C–C Bond-Forming Catalysis
    Naoya Kumagai* and Masakatsu Shibasaki*
    Synthesis 2019, 51, 185–193.
  • anti-Selective Catalytic Asymmetric Nitroaldol Reaction of α-Keto Esters: Intriguing Solvent Effect, Flow Reaction, and Synthesis of Active Pharmaceutical Ingredients
    Tomoya Karasawa, Raphaël Oriez, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2018, 140, 12290–12295.
  • Direct Catalytic Asymmetric 1,6-Conjugate Addition of Amides to p-Quinone Methides
    Zhongdong Sun, Bo Sun, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2018, 20, 3070–3073.
  • Direct Catalytic Asymmetric Aldol Reaction of α-vinyl Acetamide
    Toshifumi Takeuchi, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Org. Chem. 2018, 83, 5851–5858.
  • Direct Enolization Chemistry of 7-Azaindoline Amides: A Case Study of Bis(tetrahydrophosphole)-type Ligands
    Zhao Li, Hidetoshi Noda, Naoya Kumagai,* and Masakatsu Shibasaki*
    Tetrahedron 2018, 74, 3301–3305.
  • Catalytic Oligopeptide Synthesis
    Zijian Liu, Hidetoshi Noda, Masakatsu Shibasaki,* and Naoya Kumagai*
    Org. Lett. 2018, 20, 612–615.
  • Direct Catalytic Asymmetric Aldol Reaction of Thioamide with an α-Vinyl Appendage
    Jin Cui, Akimichi Ohtsuki, Takumi, Watanabe,* Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Eur. J. 2018, 24, 2598–2601.
  • Direct Catalytic Asymmetric Mannich-type Reaction En Route to α-Hydroxy-β-Amino Acid Derivatives
    Bo Sun, Roman Pluta, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2018, 20, 526–529.
  • Heterogeneous Heterobimetallic Catalysis Enabling Expeditious Access to CF3‑Containing vic-Amino Alcohols
    Tomoya Karasawa, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2018, 20, 308–311.
  • Structural and Computational Investigation of Intramolecular N−H Interactions in α- and β-Fluorinated 7-Azaindoline Amides
    Lennart Brewitz, Hidetoshi Noda, Naoya Kumagai,* and Masakatsu Shibasaki*
    Eur. J. Org. Chem. 2018, 714–722.
  • Bis(2-pyridyl)amides as Readily Cleavable Amides Under Catalytic, Neutral, and Room-Temperature Conditions
    Shinya Adachi, Naoya Kumagai,* and Masakatsu Shibasaki*
    Synlett 2018, 29, 301–305.
  • Catalytic Asymmetric Synthesis of α-Trifluoromethylated Carbinols: A Case Study of Tertiary Propargylic Alcohols
    Hidetoshi Noda, Naoya Kumagai,* and Masakatsu Shibasaki*
    Asian J. Org. Chem. 2018, 7, 599–612.
  • Conquering Amide Planarity: Structural Distortion and Its Hidden Reactivity
    Shinya Adachi, Naoya Kumagai,* and Masakatsu Shibasaki*
    Tetrahedron Lett. 2018, 59, 1147–1158.
  • α,β-Unsaturated Amides as Dipolarophiles: Catalytic Asymmetric Exo-selective 1,3-Dipolar Cycloaddition with Nitrones
    Ming Zhang, Naoya Kumagai,*and Masakatsu Shibasaki*
    Chem. Eur. J. 2017, 23, 12450–12455.
  • Catalytic Enantioselective Addition of Diethyl Phosphite to N-Thiophosphinoyl Ketimines: Preparation of (R)-Diethyl(1-amino-1-phenylethyl)phosphonate
    Shaoquan Lin, Yasunari Otsuka, Liang Yin, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Synth. 2017, 94, 313–331.
  • Direct Catalytic Asymmetric Aldol Addition of an α-CF3 Amide to Arylglyoxal Hydrates
    Akinobu Matsuzawa, Hidetoshi Noda, Naoya Kumagai,* Masakatsu Shibasaki*
    J. Org. Chem. 2017, 82, 8304–8308.
  • Photocatalytic α-Acylation of Ethers
    Zhongdong Sun, Naoya Kumagai,* Masakatsu Shibasaki*
    Org. Lett. 2017, 19, 3727–3730.
  • Direct N-Acylation of Sulfoximines with Carboxylic Acids Catalyzed by the B3NO2 Heterocycle
    Hidetoshi Noda, Yasuko Asada, Masakatsu Shibasaki,* and Naoya Kumagai*
    Chem. Commun. 2017, 53, 7447–7450.
  • α-Halo Amides as Competent Latent Enolates: Direct Catalytic Asymmetric Mannich-type Reaction
    Bo Sun, Pandur Venkatesan Balaji, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2017, 139, 8295–8301.
  • Cu/Pd Synergistic Dual Catalysis: Asymmetric α-Allylation of α-CF3 Amide
    Akira Saito, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2017, 56, 5551–5555.
  • Catalytic Asymmetric Synthesis of CF3-Substituted Tertiary Propargylic Alcohols via Direct Aldol Reaction of α-N3 Amide
    Hidetoshi Noda, Fuyuki Amemiya, Karin Weidner, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Sci. 2017, 8(4), 3260–3269.
  • Reversible Stereoselective Folding/Unfolding Fueled by the Interplay of Photoisomerism and Hydrogen Bonding
    Christopher R. Opie, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2017, 56, 3349–3353.
  • Unique Physicochemical and Catalytic Properties Dictated by the B3NO2 Ring System
    Hidetoshi Noda, Makoto Furutachi, Yasuko Asada, Masakatsu Shibasaki,* and Naoya Kumagai*
    Nature Chem. 2017, 9, 571–577.
  • Asymmetric Flow Catalysis: Mix-and-Go Solid-Phase Nd/Na Catalyst for Expeditious Enantioselective Access to a Key Intermediate of AZD7594
    Akihito Nonoyama, Naoya Kumagai,* and Masakatsu Shibasaki*
    Tetrahedron 2017, 73, 1517–1521.
  • Direct Catalytic Asymmetric Aldol Reaction of α-Alkylamides
    Zijian Liu, Toshifumi Takeuchi, Roman Pluta, Fernando Arteaga Arteaga, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2017, 19, 710–713.
  • Catalytic Asymmetric Synthesis of 2,3,3,3-Tetrafluoro-2-Methyl-1-Arylpropan-1-Amines as Useful Building Blocks for SAR-Studies
    Lennart Brewitz, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Fluor. Chem. 2017, 194, 1–7.
  • Pyramidalization/Twisting of the Amide Functional Group via Remote Steric Congestion Triggered by Metal Coordination
    Shinya Adachi, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Sci. 2017, 8, 85–90.
  • Strategic Immobilization of Molecular Catalysts onto Carbon Nanotubes via Noncovalent Interaction for Catalytic Organic Transformation
    Naoya Kumagai* and Masakatsu Shibasaki*
    Isr, J. Chem. 2017, 57, 270–280.
  • Enantioselective Synthesis of α,α-Disubstituted α-Amino Acids via Direct Catalytic Asymmetric Addition of Acetonitrile to α-Iminoester
    Shaoquan Lin, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Biomol. Chem. 2016, 14, 9725–9730.
  • Direct Catalytic Asymmetric Mannich-type Reaction of Alkylamides
    Fernando Arteaga Arteaga, Zijian Liu, Lennart Brewitz, Jianyang Chen, Bo Sun, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2016, 18, 2391–2394.
  • Preparation of Nd/Na Heterogeneous Catalyst from Bench-Stable and Inexpensive Nd Salt for an anti-Selective Catalytic Asymmetric Nitroaldol Reaction
    Akihito Nonoyama, Kazuki Hashimoto, Akira Saito, Naoya Kumagai,* and Masakatsu Shibasaki*
    Tetrahedron Lett. 2016, 57, 1815–1819.
  • Electrophilic Activation of α,β-Unsaturated Amides; Catalytic Asymmetric Vinylogous Conjugate Addition of Unsaturated γ-Butyrolactones
    Ming Zhang, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Eur. J. 2016, 22, 5525–5529.
  • Direct Catalytic Asymmetric Mannich-type Reaction of α,β-Unsaturated γ-Butyrolactam to Ketimines
    Shaoquan Lin, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Eur. J. 2016, 22, 3296–3299.
  • Nucleophilic and Electrophilic Activation of Non-Heteroaromatic Amides in Atom Economical Asymmetric Catalysis
    Naoya Kumagai* and Masakatsu Shibasaki*
    Chem. Eur. J. 2016, 22, 15192–15200.
  • Career in Catalysis: Masakatsu Shibasaki
    Naoya Kumagai,* Motomu Kanai,* and Hiroaki Sasai*
    ACS Catal. 2016, 6, 4699–4709.
  • Direct Catalytic Asymmetric Mannich-type Reaction of α- and β-Fluorinated Amides
    Lennart Brewitz, Fernando Arteaga Arteaga, Liang Yin, Kaliyamoorthy Alagiri, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2015, 137, 15929–15939.
  • Direct Catalytic Asymmetric Mannich-type Reaction of α-N3 Amide
    Zhongdong Sun, Karin Weidner, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Eur. J. 2015, 21, 17574–17577.
  • Stereoselective Total Synthesis of KAE609 via Direct Catalytic Asymmetric Alkynylation to Ketimine
    Hisashi Takada, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2015, 17, 4762–4765.
  • Managing the Retro-Pathway in Direct Catalytic Asymmetric Aldol Reactions of Thioamides
    Youmei Bao, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Sci. 2015, 6, 6124–6132.
  • Direct Catalytic Asymmetric Conjugate Addition of Saturated and Unsaturated Thioamides
    Nilanjana Majumdar, Akira Saito, Liang Yin, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2015, 17, 3362–3365.
  • Direct Catalytic Asymmetric Mannich-type Reaction of Benzyl Isocyanide: Stereoselective Synthesis of 1,2-Diarylethylenediamines
    Keiji Tamura, Naoya Kumagai,* and Masakatsu Shibasaki*
    Eur. J. Org. Chem. 2015, 3026–3031.
  • Direct Catalytic Asymmetric Aldol Reaction of α-N3 Amide
    Karin Weidner, Zhongdong Sun, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2015, 54, 6236–6240.
  • Catalytic Asymmetric Mannich-type Reaction of N-Alkylidene α-Aminoacetonitrile to Ketimines
    Shaoquan Lin, Yuji Kawato, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2015, 54, 5183–5186.
  • A Carbon Nanotube Confinement Strategy to Implement Homogeneous Asymmetric Catalysis in the Solid Phase
    Kazuki Hashimoto, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Eur. J. 2015, 21, 4262–4266.
  • Recent Advances in Catalytic Asymmetric C–C Bond-Forming Reactions to Ketimines Promoted by Metal-Based Catalysts
    Naoya Kumagai* and Masakatsu Shibasaki*
    Bull. Chem. Soc. Jpn. 2015, 88, 503–517.
  • Catalytic Generation of α-CF3 Enolate: Direct Catalytic Asymmetric Mannich-type Reaction of α-CF3 Amide
    Liang Yin, Lennart Brewitz, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2014, 136, 17958–17961.
  • Chromatography-Free Synthesis of Corey’s Intermediate for Tamiflu
    Makoto Furutachi, Naoya Kumagai, Takumi Watanabe,* and Masakatsu Shibasaki*
    Tetrahedron 2014, 70, 9113–9117.
  • Iterative Direct Aldol Strategy for Polypropionates: Enantioselective Total Synthesis of (–)-Membrenone A and B
    Kaliyamoorthy Alagiri, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2014, 16, 5301–5303.
  • Design and Synthesis of a Bis(hydroxyphenyl)diamide Bearing a Pendant Thiazolium Unit; Application to the Catalytic Asymmetric Intramolecular Stetter Reaction
    Youmei Bao, Naoya Kumagai,* and Masakatsu Shibasaki*
    Tetrahedron: Asymmetry 2014, 25, 1401–1408.
  • Direct Catalytic Addition of Alkylnitriles to Aldehydes by Transition Metal/NHC Complexes
    Devarajulu Sureshkumar, Venkataraman Ganesh, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Eur. J. 2014, 20, 15723–15726.
  • Self-Assembled Asymmetric Catalyst Engaged in a Continuous-Flow Platform: An anti-Selective Catalytic Asymmetric Nitroaldol Reaction
    Kazuki Hashimoto, Naoya Kumagai,* Masakatsu Shibasaki*
    Org. Lett. 2014, 16, 3496–3499.
  • A Designed Amide as an Aldol Donor in the Direct CatalyticAsymmetric Aldol Reaction
    Karin Weidner, Naoya Kumagai,* and Masakatsu
    Shibasaki*
    Angew. Chem., Int. Ed. 2014, 53, 6150–6154.
  • Concise Enantioselective Synthesis of δ,δ-Disubstituted δ-Valerolactones
    Akira Saito, Naoya Kumagai,* and Masakatsu Shibasaki*
    Tetrahedron Lett. 2014, 55, 3167–3171.
  • An Enantioselective Synthesis of the Key Intermediate for Triazole Antifungal Agents; Application to the Catalytic Asymmetric Synthesis of Efinaconazole (Jublia®)
    Keiji Tamura, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Org. Chem. 2014, 79, 3272–3278.
  • Direct Catalytic Asymmetric Vinylogous Conjugate Addition of Unsaturated Butyrolactones to α,β-Unsaturated Thioamides
    Liang Yin, Hisashi Takada, Shaoquan Lin, Naoya Kumagai,* Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2014, 53, 5327–5331.
  • Direct Aldol Strategy in Enantioselective Total Synthesis of Thuggacin B
    Akinobu Matsuzawa, Christopher R. Opie, Naoya Kumagai,* Masakatsu Shibasaki*
    Chem. Eur. J. 2014, 20, 68–71.
  • A Modified Preparation Procedure for Carbon Nanotube-Confined Nd/Na Heterobimetallic Catalyst for anti-Selective Catalytic Asymmetric Nitroaldol Reactions
    Devarajulu Sureshkumar, Kazuki Hashimoto, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Org. Chem. 2013, 78, 11494–11500.
  • Direct Catalytic Asymmetric Addition of Acetonitrile to N-Thiophosphinoylimines
    Yuji Kawato, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Commun. 2013, 49, 11227–11229.
  • An Enantioselective Synthesis of Voriconazole
    Keiji Tamura, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Org. Chem. 2013, 78, 11396–11403.
  • Catalytic Asymmetric Hydrophosphonylation of Ketimines
    Liang Yin, Youmei Bao, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Am Chem. Soc. 2013, 135, 10338–10341.
  • Direct Catalytic Asymmetric Vinylogous Mannich-type Reaction of γ-Butenolides to Ketimines
    Liang Yin, Hisashi Takada, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2013, 52, 7310–7313.
  • Direct Catalytic Asymmetric Mannich-type Reaction of α-Sulfanyl Lactones
    Sho Takechi, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2013, 15, 2632–2635.
  • Self-Assembling Nd/Na Heterobimetallic Asymmetric Catalyst Confined in Carbon Nanotube Network
    Takanori Ogawa, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2013, 52, 6196–6201.
  • In situ Manipulation of Catalyst Performance via Photocontrolled Aggregation/Dissociation State of the Catalyst
    Akihiro Nojiri, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Commun. 2013, 49, 4628–4630.
  • Two Approaches toward the Formal Total Synthesis of Oseltamivir Phosphate (Tamiflu®): Catalytic Enantioselective Three-Component Reaction Strategy and L-Glutamic Acid Strategy
    Kaliyamoorthy Alagiri, Makoto Furutachi, Kenzo Yamatsugu, Naoya Kumagai, Takumi Watanabe,* and Masakatsu Shibasaki*
    J. Org. Chem. 2013, 78, 4019–4026.
  • Streamlined Catalytic Asymmetric Synthesis of Atorvastatin
    Yuji Kawato, Sandeep Chaudhary, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Eur. J. 2013, 19, 3802–3806.
  • Direct Catalytic Asymmetric Alkynylation of Ketoimines
    Liang Yin, Yasunari Otsuka, Hisashi Takada, Shinsuke Mouri, Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett 2013, 15, 698–701.
  • Direct Catalytic Asymmetric Addition of Allylic Cyanides to Aldehydes for Expeditious Access to Enantioenriched Unsaturated δ-Valerolactones
    Yasunari Otsuka, Hisashi Takada, Shigeo Yasuda, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Asian J. 2013, 8, 354–358.
  • Asymmetric Catalysis with Bis(hydroxyphenyl)diamides/Rare Earth Metal Complexes
    Naoya Kumagai* and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2013, 52, 223–234.
  • Catalytic Chemical Transformations with Conformationally Dynamic Catalytic Systems
    Naoya Kumagai* and Masakatsu Shibasaki*
    Catal. Sci. Technol. 2013, 3, 41–57.
  • Direct Asymmetric α-Allylation of Ketones with Allylic Alcohols via Pd/Enamine Cooperative Function
    Shigeo Yasuda, Naoya Kumagai,* and Masakatsu Shibasaki*
    Heterocycles 2012, 86, 745–757.
  • Catalytic Asymmetric Conjugate Addition of Thiols to α,β-Unsaturated Thioamides: Expeditious Access to Enantioenriched 1,5-Benzothiazepines
    Takanori Ogawa, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2012, 51, 8551–8554.
  • anti-Selective Direct Catalytic Asymmetric Aldol Reaction of Thiolactams
    Devarajulu Sureshkumar, Yuji Kawato, Mitsutaka Iwata, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2012, 14, 3108–3111.
  • Concise Enantioselective Synthesis of Duloxetine via Direct Catalytic Asymmetric Aldol Reaction of Thioamide
    Yuta Suzuki, Mitsutaka Iwata, Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Org. Chem. 2012, 77, 4496–4500.
  • A Direct Catalytic Asymmetric Aldol Reaction of α-Sulfanyl Lactones: Efficient Synthesis of SPT Inhibitors
    Sho Takechi, Shigeo Yasuda, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2012, 51, 4218-4222.
  • Reversible Heterochiral Aggregation/Dissociation of Bis(2-hydroxyphenyl)diamides Driven by UV/Vis Irradiation
    Akihiro Nojiri, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2012, 51, 2137–2141.
  • Catalytic Asymmetric anti-Selective Nitroaldol Reaction En Route to Zanamivir
    Tatsuya Nitabaru, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2012, 51, 1644–1647.
  • Intermediate as Catalyst; Catalytic Asymmetric Conjugate Addition of Nitroalkanes to α,β-Unsaturated Thioamides
    Takanori Ogawa, Shinsuke Mouri, Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2012, 14, 110–113.
  • Cooperative Catalysis Using Thioamides Toward Truly Practical Organic Synthesis
    Naoya Kumagai* and Masakatsu Shibasaki*
    Isr. J. Chem. 2012, 52, 604–612.
  • Direct Catalytic Asymmetric Intramolecular Conjugate Addition of Thioamide to α,β-Unsaturated Esters
    Yuta Suzuki, Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Eur. J. 2011, 17, 11998–12001.
  • Asymmetric Synthesis of Isothiazoles Through Cu Catalysis: Direct Catalytic Asymmetric Conjugate Addition of Allyl Cyanide to α,β-Unsaturated Thioamides
    Yuka Yanagida, Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2011, 50, 7910–7914.
  • La/Ag Cooperative Cooperative Heterobimetallic Catalysis: A Catalytic Asymmetric Conia-ene Reaction
    Tomoyuki Mashiko, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2011, 50, 7616–7619.
  • A Simplified Catalytic System for Direct Catalytic Asymmetric Aldol Reaction of Thioamides; Application to an Enantioselective Synthesis of Atorvastatin
    Yuji Kawato, Mitsutaka Iwata, Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki*
    Tetrahedron 2011, 67, 6539–6546.
  • Direct Catalytic Enantio- and Diastereoselective Aldol Reaction of Thioamides
    Mitsutaka Iwata, Ryo Yazaki, I-Hon Chen, Devarajulu Sureshkumar, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2011, 133, 5554–5560.
  • Cooperative Activation of Alkyne and Thioamide Functionalities; Direct Catalytic Asymmetric Conjugate Addition of Terminal
    Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Asian J. 2011, 6, 1778–1790.
  • Enantioselective Synthesis of a GPR40 Agonist AMG 837 via Catalytic Asymmetric Conjugate Addition of Terminal Alkyne to α,β-Unsaturated Thioamide
    Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2011, 13, 952–955.
  • Catalytic Asymmetric Hydroxylation of α-Alkoxycarbonyl Amides with a Pr(OiPr)3/Amide-Based Ligand Catalyst
    Sho Takechi, Naoya Kumagai,* and Masakatsu Shibasaki*
    Tetrahedron Lett. 2011, 52, 2140–2143.
  • Catalytic Asymmetric Amination of N-Nonsubstituted α-Alkoxycarbonyl Amides: Concise Enantioselective Synthesis of Mycestericin F and G
    Farouk Berhal, Sho Takechi, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Eur. J. 2011, 17, 1915–1921.
  • Expanding Stereochemical and Skeletal Diversity Derived from Petasis Reactions Using 1,3-Dipolar Cycloadditions
    Giovanni Muncipinto, Taner Kaya, J. Anthony Wilson, Naoya Kumagai, Paul A. Clemons, and Stuart L. Schreiber*
    Org. Lett. 2010, 12, 5230–5233.
  • Recent Advances in Direct Catalytic Asymmetric Transformations Under Proton-Transfer Conditions
    Naoya Kumagai* and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2011, 50, 4760–4772.
  • Development of Atom-Economical Catalytic Asymmetric Reactions Under Proton Transfer Conditions: Construction of Tetrasubstituted Stereogenic Centers and Their Application to Therapeutics
    Naoya Kumagai*
    Chem. Pharm. Bull. 2011, 59, 1–22.
  • Direct Catalytic Asymmetric Conjugate Addition of Terminal Alkynes to α,β-Unsaturated Thioamides
    Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2010, 132, 10275–10277.
  • Direct Catalytic Asymmetric Aldol Reaction of Thioamides: A Concise Asymmetric Synthesis of (R)-Fluoxetine
    Mitsutaka Iwata, Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki*
    Tetrahedron: Asymmetry 2010, 21, 1688–1694.
  • Solvent-Dependent Self-Discrimination of Bis(2-hydroxyphenyl)diamides
    Akinobu Matsuzawa, Akihiro Nojiri, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Eur. J. 2010, 16, 5036–5042.
  • Direct Catalytic Asymmetric Addition of Allyl Cyanide to Ketones via Soft Lewis Acid/Hard Brønsted Base/Hard Lewis Base Catalysis
    Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2010, 132, 5522–5531.
  • Catalytic Asymmetric Conjugate Addition of α-Cyanoketones For the Construction of a Quaternary Stereogenic Center
    Yuji Kawato, Noriko Takahashi, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2010, 12, 1484–1487.
  • Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst
    Tatsuya Nitabaru, Naoya Kumagai,* and Masakatsu Shibasaki*
    Molecules 2010, 15, 1280–1290.
  • Direct Catalytic Asymmetric Aldol Reactions of Thioamides: Toward a Stereocontrolled Synthesis of 1,3-Polyols
    Iwata, Ryo Yazaki, Yuta Suzuki, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2009, 131, 18244–18245.
  • Managing Highly Coordinative Substrates in Asymmetric Catalysis: a Catalytic Asymmetric Amination with a Lanthanum-based Ternary Catalyst
    Tomoyuki Mashiko, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2009, 131, 14990–14999.
  • anti-Selective Catalytic Asymmetric Nitroaldol Reaction via a Heterobimetallic Heterogeneous Catalyst
    Tatsuya Nitabaru, Akihiro Nojiri, Makoto Kobayashi, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2009, 131, 13860–13869.
  • Direct Catalytic Asymmetric Mannich-type Reaction of Thioamides
    Yuta Suzuki, Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2009, 48, 5026–5029.
  • Linking Structural Dynamics and Functional Diversity in Asymmetric Catalysis
    Akihiro Nojiri, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2009, 131, 3779–3784.
  • Direct Catalytic Asymmetric Addition of Allyl Cyanide to Ketones
    Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2009, 131, 3195–3197.
  • Inventing and Understanding Catalytic, Enantioselective Reactions
    Masakatsu Shibasaki,* Naoya Kumagai, and Tomoyuki Mashiko
    Curr. Opin. Drug Discov. Dev. 2009, 12, 862–875.
  • Recent Progress in Asymmetric Bifunctional Catalysis Using Multimetallic Systems
    Masakatsu Shibasaki,* Motomu Kanai, Shigeki Matsunaga, and Naoya Kumagai
    Acc. Chem. Res. 2009, 42, 1117–1127.
  • Direct Catalytic Asymmetric Addition of Allylic Cyanides to Ketoimines
    Ryo Yazaki, Tatsuya Nitabaru, Naoya Kumagai,* and Masakatsu Shibasaki* 
    J. Am. Chem. Soc. 2008, 130, 14477–14479.
  • An Improved Lanthanum Catalyst System for Asymmetric Amination; Toward a Practical Asymmetric Synthesis of AS-3201 (Ranirestat)
    Tomoyuki Mashiko, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2008, 10, 2725–2728.
  • Asymmetric Catalysis via Dynamic Substrate/Ligand/Rare Earth Metal Conglomerate
    Akihiro Nojiri, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2008, 130, 5630–5631.
  • A Catalytic Asymmetric anti-Selective Nitroaldol Reaction with a Neodymium-Sodium Heterobimetallic Complex
    Tatsuya Nitabaru, Naoya Kumagai,* and Masakatsu Shibasaki*
    Tetrahedron Lett. 2008, 49, 272–276.
  • En Route to an Efficient Catalytic Asymmetric Synthesis of AS-3201
    Tomoyuki Mashiko, Keiichi Hara, Daisuke Tanaka, Yuji Fujiwara, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2007, 129, 11342–11343.
  • Catalytic Nucleophilic Activation of Acetonitrile via a Cooperative Catalysis of Cationic Ru Complex, DBU, and NaPF6
    Naoya Kumagai,* Shigeki Matsunaga, and Masakatsu Shibasaki*
    Tetrahedron 2007, 63, 8598–8608.
  • Short Synthesis of Skeletally and Stereochemically Diverse Small Molecules by Coupling Petasis Condensation Reactions to Cyclization Reactions
    Naoya Kumagai, Giovanni Muncipinto, and Stuart L. Schreiber*
    Angew. Chem., Int. Ed. 2006, 45, 3635–3638.
  • Catalytic Chemoselective Addition of Acetonitrile to Enolizable Aldehydes with Cationic Ru Complex/DBU Combination
    Naoya Kumagai, Shigeki Matsunaga, and Masakatsu Shibasaki*
    Chem. Commun. 2005, 3600–3602.
  • Non-C2-symmetric, Chirally Economical, and Readily Tunable Linked-BINOLs: Design and Application in Direct Asymmetric Mannich-type Reaction
    Takamasa Yoshida, Hiroyuki Morimoto, Naoya Kumagai, Shigeki Matsunaga, and Masakatsu Shibasaki*
    Angew. Chem. Int. Ed. 2005, 44, 3470–3474.
  • An Efficient Synthesis of Bicyclic Amidines by Intramolecular Cyclization
    Naoya Kumagai, Shigeki Matsunaga, and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2004, 43, 478–482
  • Direct catalytic Asymmetric Mannich-type Reaction of Hydroxyketone Using a Et2Zn/linked-BINOL Complex: Synthesis of Either anti-α or syn-β-Amino Alcohols
    Shigeki Matsunaga, Takamasa Yoshida, Hiroyuki Morimoto, Naoya Kumagai, and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2004, 126, 8277–8785.
  • Cooperative Catalysis of a Cationic Ruthenium Complex, Amine Base, and Na Salt: Catalytic Activation of Acetonitrile as Nucleophile
    Naoya Kumagai, Shigeki Matsunaga, and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2004, 126, 13632–13633.
  • Direct Catalytic Aldol-Type Reactions Using RCH2CN
    Yutaka Suto, Naoya Kumagai, Shigeki Matsunaga, Motomu Kanai, and Maskatsu Shibasaki*
    Org. Lett. 2003, 5, 3147–3150.
  • anti-Selective Direct Catalytic Asymmetric Mannich-type Reaction of Hydroxyketone Providing β-Amino Alcohols
    Shigeki Matsunaga, Naoya Kumagai, Shinji Harada, and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2003, 125, 4712–4713.
  • Direct Catalytic Asymmetric Michael Reaction of Hydroxyketones: Asymmetric Zn Catalysis with a Et2Zn/Linked-BINOL Complex
    Shinji Harada, Naoya Kumagai, Tomofumi Kinoshita, Shigeki Matsunaga, and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2003, 125, 2582–2590.
  • Direct Catalytic Asymmetric Aldol Reaction of Hydroxyketones: Asymmetric Zn Catalysis with a Et2Zn/Linked-BINOL Complex
    Naoya Kumagai, Shigeki Matsunaga, Tomofumi Kinoshita, Shinji Harada, Shigemitsu Okada, Shigeru Sakamoto, Kentaro Yamaguchi, and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2003, 125, 2169–2178.
  • Enantioselective 1,4-Addition of Unmodified Ketone Catalyzed by a Bimetallic Zn-Zn-linked-BINOL Complex
    Naoya Kumagai, Shigeki Matsunaga and Masakatsu Shibasaki*
    Org. Lett. 2001, 3, 4251–4254.
  • Direct Catalytic Enantio- and Diastereoselective Aldol Reaction Using a Zn-Zn-Linked-BINOL Complex: A Practical Synthesis of syn-1,2-Diols
    Naoya Kumagai, Shigeki Matsunaga, Naoki Yoshikawa, Takashi Ohshima, and Masakatsu Shibasaki*
    Org. Lett. 2001, 3, 1539–1542.
  • Direct Catalytic Asymmetric Aldol Reaction: Synthesis of Either syn– or anti-α,β-Dihydroxyketones
    Naoki Yoshikawa, Naoya Kumagai, Shigeki Matsunaga, Guido Moll, Takashi Ohshima, Takeyuki Shzuki, and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2001, 123, 2466–2467.
  • An Efficient Method for the Synthesis of Versatile Intermediate Leading to 13-Deoxy- and 9,13-Dideoxyphorbors
    Akihiro Sekine, Naoya Kumagai, Koichiro Uotsu, Takashi Ohshima, and Masakatsu Shibasaki*
    Tetrahedron Lett. 2000, 41, 509–513.
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