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PUBLICATIONS

  • DiazaChrysenes (DC): Nitrogen-Containing π-Extended Molecules for Photocatalytic C–H Amination
    Wei Xu, Atsushi Iwai, Itsuki Nagasaka, Satsuki Watanabe, Ryosuke Tsutsumi, and Naoya Kumagai*
    Org. Lett. 2025, 27, 10937–10942.
  • Enlarged-TriQuinoline (Enl-TQ): Disparity in Chemical Behaviors by Geometric Scaling of the Trimeric Quinoline Ring System
    Mai Yamashita, Ryosuke Tsutsumi, Toi Kobayashi, and Naoya Kumagai*
    Chem. Asian J. 2025, 20, e00429.
  • iso-TEtraQuinoline (i-TEQ): An Inherently Chiral N4 Macrocyclic Quinoline Tetramer
    Ryota Yagami, Wei Xu, Toi Kobayashi, Yuuya Nagata, and Naoya Kumagai*
    Chem. Sci. 2025, 16, 10714–10721.
  • キノリンを構成単位とする大環状システムの創出と多彩な化学への展開
    (Development of Unique Quinoline–Based Macrocyclic Systems and Strategic Applications in Versatile Chemistry)
    Toi Kobayashi, Wei Xu, and Naoya Kumagai*
    J. Synth. Org. Chem. Jpn. 2025, 83, 386–394.
  • DiQuinoline-MonoQuinazoline: A Flat Proton Binder and Its Application as a Polyaromatic Hydrocarbon Scavenger and G4 Ligand
    Taiga Karimata, Wei Xu, and Naoya Kumagai*
    Chem. Eur. J. 2025, 31, e202404335.
  • In2Q2: A New Entry of 16-Membered Tetraazamacrocycle Concatenating Indole and Quinoline Units
    Kazuki Kihara, Toi Kobayashi, Wei Xu, and Naoya Kumagai*
    Chem. Eur. J. 2024, 30, e202304176.
  • Recent Advances in Quinoline-based Macrocycles: Synthesis, Properties, and Applications in Catalytic Reactions
    Wei Xu and Naoya Kumagai*
    Synthesis 2024, 56, 1765–1774.
  • Peripheral Modification of Tripodal Aza-Oxa-Crown oxa-TriQuinoline
    Toi Kobayashi, Takuya Sakurai, and Naoya Kumagai*
    Bull. Chem. Soc. Jpn. 2023, 96, 1139–1143.
  • Oxa-TriQuinoline: A New Entry to Aza-Oxa-Crown Architectures
    Toi Kobayashi and Naoya Kumagai*
    Angew. Chem. Int. Ed. 2023, 62, e202307896.
  • Chemoselective Catalytic Dehydrogenation of Benzylic Amines Driven by TEtraQuinoline/FeCl2 Complex
    Mizuki Nishiwaki, Wei Xu, and Naoya Kumagai*
    Asian J. Org. Chem. 2023, e202300261.
  • A Brief Introduction of Highly Symmetrical N-Heteroarene-based Heterocycles
    Wei Xu and Naoya Kumagai*
    Tetrahedron 2023, 141, 133512.
  • Expeditious Access to the B3NO2 Heterocycle Enabling Modular Derivatization
    Ryosuke Tsutsumi, Nobuaki Kashiwagi, and Naoya Kumagai*
    J. Org. Chem. 2023, 88, 6247–6251.
  • Azo-Tagged C4N4 Fluorophores: Unusual Overcrowded Structures and Their Applications to Fluorescent Imaging
    Miki Kohei, Naoki Takizawa, Ryosuke Tsutsumi, Wei Xu, and Naoya Kumagai*
    Org. Biomol. Chem. 2023, 21, 2889–2893.
  • Less Is More: N(BOH)2 Configuration Exhibits Higher Reactivity than the B3NO2 Heterocycle in Catalytic Dehydrative Amide Formation
    Christopher R. Opie, Hidetoshi Noda,* Masakatsu Shibasaki, and Naoya Kumagai*
    Org. Lett. 2023, 25, 694–697.
  • TEtraQuinolines: A Missing Link in the Family of Porphyrinoid Macrocycles
    Wei Xu, Yuuya Nagata, and Naoya Kumagai*
    J. Am. Chem. Soc. 2023, 145, 2609–2618.
  • Oxygen-Fueled Iterative Hydride Transfer Driven by a Rigid Planar Architecture
    Taiga Karimata, Shinya Adachi, Masakatsu Shibasaki, and Naoya Kumagai*
    Chem. Pharm. Bull. 2022, 70, 595–598.
  • Highly Enantio- and Diastereoselective Synthesis of 1,2,3-Trisubstituted Cyclopropanes from α,β-Unsaturated Amides and Stabilized Sulfur Ylides Catalyzed by a Chiral Copper(I) Complex
    Santosh K. Pagire, Naoya Kumagai,* and Masakatsu Shibasaki*
    ACS Catal. 2021, 11, 11597–11606.
  • Strategic Synthesis of Asymmetrically Substituted C4N4 Fluorophores
    Wei Xu, Miki Kohei, Masakatsu Shibasaki,* and Naoya Kumagai*
    Synthesis 2021, 53, 3355–3360.
  • Direct Catalytic Asymmetric Addition of Aklylnitriles to Aldehydes with Designed Ni-Carbene Complexes
    Akira Saito, Shinya Adachi, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem. Int. Ed. 2021, 60, 8739–8743.
  • Direct Catalytic Asymmetric Addition of α‐Fluoronitriles to Aldehydes
    Pandur V. Balaji, Zhao Li, Akira Saito, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Eur. J. 2020, 26, 15524–15527.
  • Design, Synthesis, and Application of Multiboron Heterocycle to Direct Amidation Catalyst
    Hidetoshi Noda, Masakatsu Shibasaki,* and Naoya Kumagai*
    J. Synth. Org. Chem. Jpn. 2020, 78, 971–978.
  • The Different Faces of [Ru(bpy)3Cl2] and fac[Ir(ppy)3] Photocatalysts: Redox Potential Controlled Synthesis of Sulfonylated Fluorenes and Pyrroloindoles from Unactivated Olefins and Sulfonyl Chlorides
    Santosh K. Pagire, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2020, 22, 7853–7858.
  • Direct Catalytic Asymmetric and anti-Selective Vinylogous Addition of Butenolides to Chromones
    Jin Cui, Naoya Kumagai, Takumi Watanabe,* and Masakatsu Shibasaki*
    Chem. Sci. 2020, 11, 7170–7176.
  • Introduction of a 7-Aza-6-MeO-indoline Auxiliary in Lewis acid/Photoredox Cooperative Catalysis: Highly Enantioselective Aminomethylation of α,β-Unsaturated Amides
    Santosh K. Pagire, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Sci. 2020, 11, 5168–5174.
  • Catalytic Asymmetric 1,3-Dipolar Cycloaddition of α,β-Unsaturated Amide and Azomethine Imine
    Zhao Li, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Pharm. Bull. 2020, 68, 552–554.
  • (2R,3S)-3,4,4,4-Tetrafluorovaline: A Fluorinated Bioisostere of Isoleucine
    Lennart Brewitz, Hidetoshi Noda, Naoya Kumagai,* and Masakatsu Shibasaki*
    Eur. J. Org. Lett. 2020, 1745–1752.
  • Z-Enolate Geometry in Thioamide Aldol Reaction Illuminated by 7-Azaindoline Auxiliary
    Roman Pluta, Zhao Li, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2020, 22, 791–794.
  • TriQuinoline
    Shinya Adachi, Masakatsu Shibasaki, and Naoya Kumagai*
    Nature Commun. 2019, 10, 3820.
  • Direct Catalytic Asymmetric Addition of Acetonitrile to Aldimines
    Akira Saito, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2019, 21, 8187–8190.
  • Solvent-Dependent Enantio-divergence in anti-Selective Catalytic Asymmetric Nitroaldol Reactions
    Tomoya Karasawa, Akira Saito, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2019, 21, 3581–3583.
  • A Thirst for Enantioselectivity in Catalytic Asymmetric Addition of Alkylnitriles
    Naoya Kumagai* and Masakatsu Shibasaki*
    Chem. Lett. 2019, 48, 1322–1327.
  • All Non-Carbon B3NO2 Exotic Heterocycle: Synthesis, Dynamics, and Catalysis
    Christopher R. Opie, Hidetoshi Noda, Masakatsu Shibasaki,* and Naoya Kumagai*
    Chem. Eur. J. 2019, 25, 4648–4653.
  • A C4N4 Diaminopyrimidine Fluorophore
    Hidetoshi Noda, Yasuko Asada, Tatsuro Maruyama, Naoki Takizawa, Nobuo N. Noda, Masakatsu Shibasaki,* and Naoya Kumagai*
    Chem. Eur. J. 2019, 25, 4299–4304.
  • Direct Catalytic Asymmetric Aldol Reaction of α-Alkoxyamides to α-Fluorinated Ketones
    Roman Pluta, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem. Int. Ed. 2019, 58, 2459–2463.
  • Neighboring Protonation Unveils Lewis Acidity in the B3NO2 Heterocycle
    Hidetoshi Noda, Yasuko Asada, Masakatsu Shibasaki,* and Naoya Kumagai*
    J. Am. Chem. Soc. 2019, 141, 1546–1554.
  • A Fluorogenic C4N4 Probe for Azide-Based Labelling
    Hidetoshi Noda, Yasuko Asada, Masakatsu Shibasaki,* and Naoya Kumagai*
    Org. Biomol. Chem. 2019, 17, 1813–1816.
  • Catalytic Asymmetric Synthesis of syn-Aldols with Methyl Ketone Functionality and anti-Aldol with a Thioamide Group
    Yuya Ota, Zhao Li, Naoya Kumagai,* and Masakatsu Shibasaki*
    Synlett 2019, 30, 620–624.
  • Achiral Trisubstituted Thioureas as Secondary Ligands to Cu(I) Catalysts: Direct Catalytic Asymmetric Addition of α-Fluoronitriles to Imines
    Pandur Venkatesan Balaji, Lennart Brewitz, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem. Int. Ed. 2019, 58, 2644–2648.
  • Direct Catalytic Asymmetric Mannich-Type Reaction of an α-Isatine Amide to Isatin Imines
    Jin-Sheng Yu, Hidetoshi Noda, Naoya Kumagai,* and Masakatsu Shibasaki*
    Synlett 2019, 30, 488–492.
  • 7-Azaindoline Auxiliary: A Versatile Attachment Facilitating Enantioselective C–C Bond-Forming Catalysis
    Naoya Kumagai* and Masakatsu Shibasaki*
    Synthesis 2019, 51, 185–193.
  • anti-Selective Catalytic Asymmetric Nitroaldol Reaction of α-Keto Esters: Intriguing Solvent Effect, Flow Reaction, and Synthesis of Active Pharmaceutical Ingredients
    Tomoya Karasawa, Raphaël Oriez, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2018, 140, 12290–12295.
  • Direct Catalytic Asymmetric 1,6-Conjugate Addition of Amides to p-Quinone Methides
    Zhongdong Sun, Bo Sun, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2018, 20, 3070–3073.
  • Direct Catalytic Asymmetric Aldol Reaction of α-vinyl Acetamide
    Toshifumi Takeuchi, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Org. Chem. 2018, 83, 5851–5858.
  • Direct Enolization Chemistry of 7-Azaindoline Amides: A Case Study of Bis(tetrahydrophosphole)-type Ligands
    Zhao Li, Hidetoshi Noda, Naoya Kumagai,* and Masakatsu Shibasaki*
    Tetrahedron 2018, 74, 3301–3305.
  • Catalytic Oligopeptide Synthesis
    Zijian Liu, Hidetoshi Noda, Masakatsu Shibasaki,* and Naoya Kumagai*
    Org. Lett. 2018, 20, 612–615.
  • Direct Catalytic Asymmetric Aldol Reaction of Thioamide with an α-Vinyl Appendage
    Jin Cui, Akimichi Ohtsuki, Takumi, Watanabe,* Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Eur. J. 2018, 24, 2598–2601.
  • Direct Catalytic Asymmetric Mannich-type Reaction En Route to α-Hydroxy-β-Amino Acid Derivatives
    Bo Sun, Roman Pluta, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2018, 20, 526–529.
  • Heterogeneous Heterobimetallic Catalysis Enabling Expeditious Access to CF3‑Containing vic-Amino Alcohols
    Tomoya Karasawa, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2018, 20, 308–311.
  • Structural and Computational Investigation of Intramolecular N−H Interactions in α- and β-Fluorinated 7-Azaindoline Amides
    Lennart Brewitz, Hidetoshi Noda, Naoya Kumagai,* and Masakatsu Shibasaki*
    Eur. J. Org. Chem. 2018, 714–722.
  • Bis(2-pyridyl)amides as Readily Cleavable Amides Under Catalytic, Neutral, and Room-Temperature Conditions
    Shinya Adachi, Naoya Kumagai,* and Masakatsu Shibasaki*
    Synlett 2018, 29, 301–305.
  • Catalytic Asymmetric Synthesis of α-Trifluoromethylated Carbinols: A Case Study of Tertiary Propargylic Alcohols
    Hidetoshi Noda, Naoya Kumagai,* and Masakatsu Shibasaki*
    Asian J. Org. Chem. 2018, 7, 599–612.
  • Conquering Amide Planarity: Structural Distortion and Its Hidden Reactivity
    Shinya Adachi, Naoya Kumagai,* and Masakatsu Shibasaki*
    Tetrahedron Lett. 2018, 59, 1147–1158.
  • α,β-Unsaturated Amides as Dipolarophiles: Catalytic Asymmetric Exo-selective 1,3-Dipolar Cycloaddition with Nitrones
    Ming Zhang, Naoya Kumagai,*and Masakatsu Shibasaki*
    Chem. Eur. J. 2017, 23, 12450–12455.
  • Catalytic Enantioselective Addition of Diethyl Phosphite to N-Thiophosphinoyl Ketimines: Preparation of (R)-Diethyl(1-amino-1-phenylethyl)phosphonate
    Shaoquan Lin, Yasunari Otsuka, Liang Yin, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Synth. 2017, 94, 313–331.
  • Direct Catalytic Asymmetric Aldol Addition of an α-CF3 Amide to Arylglyoxal Hydrates
    Akinobu Matsuzawa, Hidetoshi Noda, Naoya Kumagai,* Masakatsu Shibasaki*
    J. Org. Chem. 2017, 82, 8304–8308.
  • Photocatalytic α-Acylation of Ethers
    Zhongdong Sun, Naoya Kumagai,* Masakatsu Shibasaki*
    Org. Lett. 2017, 19, 3727–3730.
  • Direct N-Acylation of Sulfoximines with Carboxylic Acids Catalyzed by the B3NO2 Heterocycle
    Hidetoshi Noda, Yasuko Asada, Masakatsu Shibasaki,* and Naoya Kumagai*
    Chem. Commun. 2017, 53, 7447–7450.
  • α-Halo Amides as Competent Latent Enolates: Direct Catalytic Asymmetric Mannich-type Reaction
    Bo Sun, Pandur Venkatesan Balaji, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2017, 139, 8295–8301.
  • Cu/Pd Synergistic Dual Catalysis: Asymmetric α-Allylation of α-CF3 Amide
    Akira Saito, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2017, 56, 5551–5555.
  • Catalytic Asymmetric Synthesis of CF3-Substituted Tertiary Propargylic Alcohols via Direct Aldol Reaction of α-N3 Amide
    Hidetoshi Noda, Fuyuki Amemiya, Karin Weidner, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Sci. 2017, 8(4), 3260–3269.
  • Reversible Stereoselective Folding/Unfolding Fueled by the Interplay of Photoisomerism and Hydrogen Bonding
    Christopher R. Opie, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2017, 56, 3349–3353.
  • Unique Physicochemical and Catalytic Properties Dictated by the B3NO2 Ring System
    Hidetoshi Noda, Makoto Furutachi, Yasuko Asada, Masakatsu Shibasaki,* and Naoya Kumagai*
    Nature Chem. 2017, 9, 571–577.
  • Asymmetric Flow Catalysis: Mix-and-Go Solid-Phase Nd/Na Catalyst for Expeditious Enantioselective Access to a Key Intermediate of AZD7594
    Akihito Nonoyama, Naoya Kumagai,* and Masakatsu Shibasaki*
    Tetrahedron 2017, 73, 1517–1521.
  • Direct Catalytic Asymmetric Aldol Reaction of α-Alkylamides
    Zijian Liu, Toshifumi Takeuchi, Roman Pluta, Fernando Arteaga Arteaga, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2017, 19, 710–713.
  • Catalytic Asymmetric Synthesis of 2,3,3,3-Tetrafluoro-2-Methyl-1-Arylpropan-1-Amines as Useful Building Blocks for SAR-Studies
    Lennart Brewitz, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Fluor. Chem. 2017, 194, 1–7.
  • Pyramidalization/Twisting of the Amide Functional Group via Remote Steric Congestion Triggered by Metal Coordination
    Shinya Adachi, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Sci. 2017, 8, 85–90.
  • Strategic Immobilization of Molecular Catalysts onto Carbon Nanotubes via Noncovalent Interaction for Catalytic Organic Transformation
    Naoya Kumagai* and Masakatsu Shibasaki*
    Isr, J. Chem. 2017, 57, 270–280.
  • Enantioselective Synthesis of α,α-Disubstituted α-Amino Acids via Direct Catalytic Asymmetric Addition of Acetonitrile to α-Iminoester
    Shaoquan Lin, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Biomol. Chem. 2016, 14, 9725–9730.
  • Direct Catalytic Asymmetric Mannich-type Reaction of Alkylamides
    Fernando Arteaga Arteaga, Zijian Liu, Lennart Brewitz, Jianyang Chen, Bo Sun, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2016, 18, 2391–2394.
  • Preparation of Nd/Na Heterogeneous Catalyst from Bench-Stable and Inexpensive Nd Salt for an anti-Selective Catalytic Asymmetric Nitroaldol Reaction
    Akihito Nonoyama, Kazuki Hashimoto, Akira Saito, Naoya Kumagai,* and Masakatsu Shibasaki*
    Tetrahedron Lett. 2016, 57, 1815–1819.
  • Electrophilic Activation of α,β-Unsaturated Amides; Catalytic Asymmetric Vinylogous Conjugate Addition of Unsaturated γ-Butyrolactones
    Ming Zhang, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Eur. J. 2016, 22, 5525–5529.
  • Direct Catalytic Asymmetric Mannich-type Reaction of α,β-Unsaturated γ-Butyrolactam to Ketimines
    Shaoquan Lin, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Eur. J. 2016, 22, 3296–3299.
  • Nucleophilic and Electrophilic Activation of Non-Heteroaromatic Amides in Atom Economical Asymmetric Catalysis
    Naoya Kumagai* and Masakatsu Shibasaki*
    Chem. Eur. J. 2016, 22, 15192–15200.
  • Career in Catalysis: Masakatsu Shibasaki
    Naoya Kumagai,* Motomu Kanai,* and Hiroaki Sasai*
    ACS Catal. 2016, 6, 4699–4709.
  • Direct Catalytic Asymmetric Mannich-type Reaction of α- and β-Fluorinated Amides
    Lennart Brewitz, Fernando Arteaga Arteaga, Liang Yin, Kaliyamoorthy Alagiri, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2015, 137, 15929–15939.
  • Direct Catalytic Asymmetric Mannich-type Reaction of α-N3 Amide
    Zhongdong Sun, Karin Weidner, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Eur. J. 2015, 21, 17574–17577.
  • Stereoselective Total Synthesis of KAE609 via Direct Catalytic Asymmetric Alkynylation to Ketimine
    Hisashi Takada, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2015, 17, 4762–4765.
  • Managing the Retro-Pathway in Direct Catalytic Asymmetric Aldol Reactions of Thioamides
    Youmei Bao, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Sci. 2015, 6, 6124–6132.
  • Direct Catalytic Asymmetric Conjugate Addition of Saturated and Unsaturated Thioamides
    Nilanjana Majumdar, Akira Saito, Liang Yin, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2015, 17, 3362–3365.
  • Direct Catalytic Asymmetric Mannich-type Reaction of Benzyl Isocyanide: Stereoselective Synthesis of 1,2-Diarylethylenediamines
    Keiji Tamura, Naoya Kumagai,* and Masakatsu Shibasaki*
    Eur. J. Org. Chem. 2015, 3026–3031.
  • Direct Catalytic Asymmetric Aldol Reaction of α-N3 Amide
    Karin Weidner, Zhongdong Sun, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2015, 54, 6236–6240.
  • Catalytic Asymmetric Mannich-type Reaction of N-Alkylidene α-Aminoacetonitrile to Ketimines
    Shaoquan Lin, Yuji Kawato, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2015, 54, 5183–5186.
  • A Carbon Nanotube Confinement Strategy to Implement Homogeneous Asymmetric Catalysis in the Solid Phase
    Kazuki Hashimoto, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Eur. J. 2015, 21, 4262–4266.
  • Recent Advances in Catalytic Asymmetric C–C Bond-Forming Reactions to Ketimines Promoted by Metal-Based Catalysts
    Naoya Kumagai* and Masakatsu Shibasaki*
    Bull. Chem. Soc. Jpn. 2015, 88, 503–517.
  • Catalytic Generation of α-CF3 Enolate: Direct Catalytic Asymmetric Mannich-type Reaction of α-CF3 Amide
    Liang Yin, Lennart Brewitz, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2014, 136, 17958–17961.
  • Chromatography-Free Synthesis of Corey’s Intermediate for Tamiflu
    Makoto Furutachi, Naoya Kumagai, Takumi Watanabe,* and Masakatsu Shibasaki*
    Tetrahedron 2014, 70, 9113–9117.
  • Iterative Direct Aldol Strategy for Polypropionates: Enantioselective Total Synthesis of (–)-Membrenone A and B
    Kaliyamoorthy Alagiri, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2014, 16, 5301–5303.
  • Design and Synthesis of a Bis(hydroxyphenyl)diamide Bearing a Pendant Thiazolium Unit; Application to the Catalytic Asymmetric Intramolecular Stetter Reaction
    Youmei Bao, Naoya Kumagai,* and Masakatsu Shibasaki*
    Tetrahedron: Asymmetry 2014, 25, 1401–1408.
  • Direct Catalytic Addition of Alkylnitriles to Aldehydes by Transition Metal/NHC Complexes
    Devarajulu Sureshkumar, Venkataraman Ganesh, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Eur. J. 2014, 20, 15723–15726.
  • Self-Assembled Asymmetric Catalyst Engaged in a Continuous-Flow Platform: An anti-Selective Catalytic Asymmetric Nitroaldol Reaction
    Kazuki Hashimoto, Naoya Kumagai,* Masakatsu Shibasaki*
    Org. Lett. 2014, 16, 3496–3499.
  • A Designed Amide as an Aldol Donor in the Direct CatalyticAsymmetric Aldol Reaction
    Karin Weidner, Naoya Kumagai,* and Masakatsu
    Shibasaki*
    Angew. Chem., Int. Ed. 2014, 53, 6150–6154.
  • Concise Enantioselective Synthesis of δ,δ-Disubstituted δ-Valerolactones
    Akira Saito, Naoya Kumagai,* and Masakatsu Shibasaki*
    Tetrahedron Lett. 2014, 55, 3167–3171.
  • An Enantioselective Synthesis of the Key Intermediate for Triazole Antifungal Agents; Application to the Catalytic Asymmetric Synthesis of Efinaconazole (Jublia®)
    Keiji Tamura, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Org. Chem. 2014, 79, 3272–3278.
  • Direct Catalytic Asymmetric Vinylogous Conjugate Addition of Unsaturated Butyrolactones to α,β-Unsaturated Thioamides
    Liang Yin, Hisashi Takada, Shaoquan Lin, Naoya Kumagai,* Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2014, 53, 5327–5331.
  • Direct Aldol Strategy in Enantioselective Total Synthesis of Thuggacin B
    Akinobu Matsuzawa, Christopher R. Opie, Naoya Kumagai,* Masakatsu Shibasaki*
    Chem. Eur. J. 2014, 20, 68–71.
  • A Modified Preparation Procedure for Carbon Nanotube-Confined Nd/Na Heterobimetallic Catalyst for anti-Selective Catalytic Asymmetric Nitroaldol Reactions
    Devarajulu Sureshkumar, Kazuki Hashimoto, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Org. Chem. 2013, 78, 11494–11500.
  • Direct Catalytic Asymmetric Addition of Acetonitrile to N-Thiophosphinoylimines
    Yuji Kawato, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Commun. 2013, 49, 11227–11229.
  • An Enantioselective Synthesis of Voriconazole
    Keiji Tamura, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Org. Chem. 2013, 78, 11396–11403.
  • Catalytic Asymmetric Hydrophosphonylation of Ketimines
    Liang Yin, Youmei Bao, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Am Chem. Soc. 2013, 135, 10338–10341.
  • Direct Catalytic Asymmetric Vinylogous Mannich-type Reaction of γ-Butenolides to Ketimines
    Liang Yin, Hisashi Takada, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2013, 52, 7310–7313.
  • Direct Catalytic Asymmetric Mannich-type Reaction of α-Sulfanyl Lactones
    Sho Takechi, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2013, 15, 2632–2635.
  • Self-Assembling Nd/Na Heterobimetallic Asymmetric Catalyst Confined in Carbon Nanotube Network
    Takanori Ogawa, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2013, 52, 6196–6201.
  • In situ Manipulation of Catalyst Performance via Photocontrolled Aggregation/Dissociation State of the Catalyst
    Akihiro Nojiri, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Commun. 2013, 49, 4628–4630.
  • Two Approaches toward the Formal Total Synthesis of Oseltamivir Phosphate (Tamiflu®): Catalytic Enantioselective Three-Component Reaction Strategy and L-Glutamic Acid Strategy
    Kaliyamoorthy Alagiri, Makoto Furutachi, Kenzo Yamatsugu, Naoya Kumagai, Takumi Watanabe,* and Masakatsu Shibasaki*
    J. Org. Chem. 2013, 78, 4019–4026.
  • Streamlined Catalytic Asymmetric Synthesis of Atorvastatin
    Yuji Kawato, Sandeep Chaudhary, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Eur. J. 2013, 19, 3802–3806.
  • Direct Catalytic Asymmetric Alkynylation of Ketoimines
    Liang Yin, Yasunari Otsuka, Hisashi Takada, Shinsuke Mouri, Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett 2013, 15, 698–701.
  • Direct Catalytic Asymmetric Addition of Allylic Cyanides to Aldehydes for Expeditious Access to Enantioenriched Unsaturated δ-Valerolactones
    Yasunari Otsuka, Hisashi Takada, Shigeo Yasuda, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Asian J. 2013, 8, 354–358.
  • Asymmetric Catalysis with Bis(hydroxyphenyl)diamides/Rare Earth Metal Complexes
    Naoya Kumagai* and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2013, 52, 223–234.
  • Catalytic Chemical Transformations with Conformationally Dynamic Catalytic Systems
    Naoya Kumagai* and Masakatsu Shibasaki*
    Catal. Sci. Technol. 2013, 3, 41–57.
  • Direct Asymmetric α-Allylation of Ketones with Allylic Alcohols via Pd/Enamine Cooperative Function
    Shigeo Yasuda, Naoya Kumagai,* and Masakatsu Shibasaki*
    Heterocycles 2012, 86, 745–757.
  • Catalytic Asymmetric Conjugate Addition of Thiols to α,β-Unsaturated Thioamides: Expeditious Access to Enantioenriched 1,5-Benzothiazepines
    Takanori Ogawa, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2012, 51, 8551–8554.
  • anti-Selective Direct Catalytic Asymmetric Aldol Reaction of Thiolactams
    Devarajulu Sureshkumar, Yuji Kawato, Mitsutaka Iwata, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2012, 14, 3108–3111.
  • Concise Enantioselective Synthesis of Duloxetine via Direct Catalytic Asymmetric Aldol Reaction of Thioamide
    Yuta Suzuki, Mitsutaka Iwata, Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Org. Chem. 2012, 77, 4496–4500.
  • A Direct Catalytic Asymmetric Aldol Reaction of α-Sulfanyl Lactones: Efficient Synthesis of SPT Inhibitors
    Sho Takechi, Shigeo Yasuda, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2012, 51, 4218-4222.
  • Reversible Heterochiral Aggregation/Dissociation of Bis(2-hydroxyphenyl)diamides Driven by UV/Vis Irradiation
    Akihiro Nojiri, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2012, 51, 2137–2141.
  • Catalytic Asymmetric anti-Selective Nitroaldol Reaction En Route to Zanamivir
    Tatsuya Nitabaru, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2012, 51, 1644–1647.
  • Intermediate as Catalyst; Catalytic Asymmetric Conjugate Addition of Nitroalkanes to α,β-Unsaturated Thioamides
    Takanori Ogawa, Shinsuke Mouri, Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2012, 14, 110–113.
  • Cooperative Catalysis Using Thioamides Toward Truly Practical Organic Synthesis
    Naoya Kumagai* and Masakatsu Shibasaki*
    Isr. J. Chem. 2012, 52, 604–612.
  • Direct Catalytic Asymmetric Intramolecular Conjugate Addition of Thioamide to α,β-Unsaturated Esters
    Yuta Suzuki, Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Eur. J. 2011, 17, 11998–12001.
  • Asymmetric Synthesis of Isothiazoles Through Cu Catalysis: Direct Catalytic Asymmetric Conjugate Addition of Allyl Cyanide to α,β-Unsaturated Thioamides
    Yuka Yanagida, Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2011, 50, 7910–7914.
  • La/Ag Cooperative Cooperative Heterobimetallic Catalysis: A Catalytic Asymmetric Conia-ene Reaction
    Tomoyuki Mashiko, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2011, 50, 7616–7619.
  • A Simplified Catalytic System for Direct Catalytic Asymmetric Aldol Reaction of Thioamides; Application to an Enantioselective Synthesis of Atorvastatin
    Yuji Kawato, Mitsutaka Iwata, Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki*
    Tetrahedron 2011, 67, 6539–6546.
  • Direct Catalytic Enantio- and Diastereoselective Aldol Reaction of Thioamides
    Mitsutaka Iwata, Ryo Yazaki, I-Hon Chen, Devarajulu Sureshkumar, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2011, 133, 5554–5560.
  • Cooperative Activation of Alkyne and Thioamide Functionalities; Direct Catalytic Asymmetric Conjugate Addition of Terminal
    Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Asian J. 2011, 6, 1778–1790.
  • Enantioselective Synthesis of a GPR40 Agonist AMG 837 via Catalytic Asymmetric Conjugate Addition of Terminal Alkyne to α,β-Unsaturated Thioamide
    Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2011, 13, 952–955.
  • Catalytic Asymmetric Hydroxylation of α-Alkoxycarbonyl Amides with a Pr(OiPr)3/Amide-Based Ligand Catalyst
    Sho Takechi, Naoya Kumagai,* and Masakatsu Shibasaki*
    Tetrahedron Lett. 2011, 52, 2140–2143.
  • Catalytic Asymmetric Amination of N-Nonsubstituted α-Alkoxycarbonyl Amides: Concise Enantioselective Synthesis of Mycestericin F and G
    Farouk Berhal, Sho Takechi, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Eur. J. 2011, 17, 1915–1921.
  • Expanding Stereochemical and Skeletal Diversity Derived from Petasis Reactions Using 1,3-Dipolar Cycloadditions
    Giovanni Muncipinto, Taner Kaya, J. Anthony Wilson, Naoya Kumagai, Paul A. Clemons, and Stuart L. Schreiber*
    Org. Lett. 2010, 12, 5230–5233.
  • Recent Advances in Direct Catalytic Asymmetric Transformations Under Proton-Transfer Conditions
    Naoya Kumagai* and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2011, 50, 4760–4772.
  • Development of Atom-Economical Catalytic Asymmetric Reactions Under Proton Transfer Conditions: Construction of Tetrasubstituted Stereogenic Centers and Their Application to Therapeutics
    Naoya Kumagai*
    Chem. Pharm. Bull. 2011, 59, 1–22.
  • Direct Catalytic Asymmetric Conjugate Addition of Terminal Alkynes to α,β-Unsaturated Thioamides
    Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2010, 132, 10275–10277.
  • Direct Catalytic Asymmetric Aldol Reaction of Thioamides: A Concise Asymmetric Synthesis of (R)-Fluoxetine
    Mitsutaka Iwata, Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki*
    Tetrahedron: Asymmetry 2010, 21, 1688–1694.
  • Solvent-Dependent Self-Discrimination of Bis(2-hydroxyphenyl)diamides
    Akinobu Matsuzawa, Akihiro Nojiri, Naoya Kumagai,* and Masakatsu Shibasaki*
    Chem. Eur. J. 2010, 16, 5036–5042.
  • Direct Catalytic Asymmetric Addition of Allyl Cyanide to Ketones via Soft Lewis Acid/Hard Brønsted Base/Hard Lewis Base Catalysis
    Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2010, 132, 5522–5531.
  • Catalytic Asymmetric Conjugate Addition of α-Cyanoketones For the Construction of a Quaternary Stereogenic Center
    Yuji Kawato, Noriko Takahashi, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2010, 12, 1484–1487.
  • Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst
    Tatsuya Nitabaru, Naoya Kumagai,* and Masakatsu Shibasaki*
    Molecules 2010, 15, 1280–1290.
  • Direct Catalytic Asymmetric Aldol Reactions of Thioamides: Toward a Stereocontrolled Synthesis of 1,3-Polyols
    Iwata, Ryo Yazaki, Yuta Suzuki, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2009, 131, 18244–18245.
  • Managing Highly Coordinative Substrates in Asymmetric Catalysis: a Catalytic Asymmetric Amination with a Lanthanum-based Ternary Catalyst
    Tomoyuki Mashiko, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2009, 131, 14990–14999.
  • anti-Selective Catalytic Asymmetric Nitroaldol Reaction via a Heterobimetallic Heterogeneous Catalyst
    Tatsuya Nitabaru, Akihiro Nojiri, Makoto Kobayashi, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2009, 131, 13860–13869.
  • Direct Catalytic Asymmetric Mannich-type Reaction of Thioamides
    Yuta Suzuki, Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2009, 48, 5026–5029.
  • Linking Structural Dynamics and Functional Diversity in Asymmetric Catalysis
    Akihiro Nojiri, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2009, 131, 3779–3784.
  • Direct Catalytic Asymmetric Addition of Allyl Cyanide to Ketones
    Ryo Yazaki, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2009, 131, 3195–3197.
  • Inventing and Understanding Catalytic, Enantioselective Reactions
    Masakatsu Shibasaki,* Naoya Kumagai, and Tomoyuki Mashiko
    Curr. Opin. Drug Discov. Dev. 2009, 12, 862–875.
  • Recent Progress in Asymmetric Bifunctional Catalysis Using Multimetallic Systems
    Masakatsu Shibasaki,* Motomu Kanai, Shigeki Matsunaga, and Naoya Kumagai
    Acc. Chem. Res. 2009, 42, 1117–1127.
  • Direct Catalytic Asymmetric Addition of Allylic Cyanides to Ketoimines
    Ryo Yazaki, Tatsuya Nitabaru, Naoya Kumagai,* and Masakatsu Shibasaki* 
    J. Am. Chem. Soc. 2008, 130, 14477–14479.
  • An Improved Lanthanum Catalyst System for Asymmetric Amination; Toward a Practical Asymmetric Synthesis of AS-3201 (Ranirestat)
    Tomoyuki Mashiko, Naoya Kumagai,* and Masakatsu Shibasaki*
    Org. Lett. 2008, 10, 2725–2728.
  • Asymmetric Catalysis via Dynamic Substrate/Ligand/Rare Earth Metal Conglomerate
    Akihiro Nojiri, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2008, 130, 5630–5631.
  • A Catalytic Asymmetric anti-Selective Nitroaldol Reaction with a Neodymium-Sodium Heterobimetallic Complex
    Tatsuya Nitabaru, Naoya Kumagai,* and Masakatsu Shibasaki*
    Tetrahedron Lett. 2008, 49, 272–276.
  • En Route to an Efficient Catalytic Asymmetric Synthesis of AS-3201
    Tomoyuki Mashiko, Keiichi Hara, Daisuke Tanaka, Yuji Fujiwara, Naoya Kumagai,* and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2007, 129, 11342–11343.
  • Catalytic Nucleophilic Activation of Acetonitrile via a Cooperative Catalysis of Cationic Ru Complex, DBU, and NaPF6
    Naoya Kumagai,* Shigeki Matsunaga, and Masakatsu Shibasaki*
    Tetrahedron 2007, 63, 8598–8608.
  • Short Synthesis of Skeletally and Stereochemically Diverse Small Molecules by Coupling Petasis Condensation Reactions to Cyclization Reactions
    Naoya Kumagai, Giovanni Muncipinto, and Stuart L. Schreiber*
    Angew. Chem., Int. Ed. 2006, 45, 3635–3638.
  • Catalytic Chemoselective Addition of Acetonitrile to Enolizable Aldehydes with Cationic Ru Complex/DBU Combination
    Naoya Kumagai, Shigeki Matsunaga, and Masakatsu Shibasaki*
    Chem. Commun. 2005, 3600–3602.
  • Non-C2-symmetric, Chirally Economical, and Readily Tunable Linked-BINOLs: Design and Application in Direct Asymmetric Mannich-type Reaction
    Takamasa Yoshida, Hiroyuki Morimoto, Naoya Kumagai, Shigeki Matsunaga, and Masakatsu Shibasaki*
    Angew. Chem. Int. Ed. 2005, 44, 3470–3474.
  • An Efficient Synthesis of Bicyclic Amidines by Intramolecular Cyclization
    Naoya Kumagai, Shigeki Matsunaga, and Masakatsu Shibasaki*
    Angew. Chem., Int. Ed. 2004, 43, 478–482
  • Direct catalytic Asymmetric Mannich-type Reaction of Hydroxyketone Using a Et2Zn/linked-BINOL Complex: Synthesis of Either anti-α or syn-β-Amino Alcohols
    Shigeki Matsunaga, Takamasa Yoshida, Hiroyuki Morimoto, Naoya Kumagai, and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2004, 126, 8277–8785.
  • Cooperative Catalysis of a Cationic Ruthenium Complex, Amine Base, and Na Salt: Catalytic Activation of Acetonitrile as Nucleophile
    Naoya Kumagai, Shigeki Matsunaga, and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2004, 126, 13632–13633.
  • Direct Catalytic Aldol-Type Reactions Using RCH2CN
    Yutaka Suto, Naoya Kumagai, Shigeki Matsunaga, Motomu Kanai, and Maskatsu Shibasaki*
    Org. Lett. 2003, 5, 3147–3150.
  • anti-Selective Direct Catalytic Asymmetric Mannich-type Reaction of Hydroxyketone Providing β-Amino Alcohols
    Shigeki Matsunaga, Naoya Kumagai, Shinji Harada, and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2003, 125, 4712–4713.
  • Direct Catalytic Asymmetric Michael Reaction of Hydroxyketones: Asymmetric Zn Catalysis with a Et2Zn/Linked-BINOL Complex
    Shinji Harada, Naoya Kumagai, Tomofumi Kinoshita, Shigeki Matsunaga, and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2003, 125, 2582–2590.
  • Direct Catalytic Asymmetric Aldol Reaction of Hydroxyketones: Asymmetric Zn Catalysis with a Et2Zn/Linked-BINOL Complex
    Naoya Kumagai, Shigeki Matsunaga, Tomofumi Kinoshita, Shinji Harada, Shigemitsu Okada, Shigeru Sakamoto, Kentaro Yamaguchi, and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2003, 125, 2169–2178.
  • Enantioselective 1,4-Addition of Unmodified Ketone Catalyzed by a Bimetallic Zn-Zn-linked-BINOL Complex
    Naoya Kumagai, Shigeki Matsunaga and Masakatsu Shibasaki*
    Org. Lett. 2001, 3, 4251–4254.
  • Direct Catalytic Enantio- and Diastereoselective Aldol Reaction Using a Zn-Zn-Linked-BINOL Complex: A Practical Synthesis of syn-1,2-Diols
    Naoya Kumagai, Shigeki Matsunaga, Naoki Yoshikawa, Takashi Ohshima, and Masakatsu Shibasaki*
    Org. Lett. 2001, 3, 1539–1542.
  • Direct Catalytic Asymmetric Aldol Reaction: Synthesis of Either syn– or anti-α,β-Dihydroxyketones
    Naoki Yoshikawa, Naoya Kumagai, Shigeki Matsunaga, Guido Moll, Takashi Ohshima, Takeyuki Shzuki, and Masakatsu Shibasaki*
    J. Am. Chem. Soc. 2001, 123, 2466–2467.
  • An Efficient Method for the Synthesis of Versatile Intermediate Leading to 13-Deoxy- and 9,13-Dideoxyphorbors
    Akihiro Sekine, Naoya Kumagai, Koichiro Uotsu, Takashi Ohshima, and Masakatsu Shibasaki*
    Tetrahedron Lett. 2000, 41, 509–513.
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